As mentioned on the Product Specification Sheet, this product can be dissolved in warm water ? 2.0 mg/ml. The exact concentration will be listed on the lot specific Certificate of Analysis. A Certificate can be accessed in the DOCUMENTATION section under 'Certificate of Analysis'. Please see the link below:
https://www.sigmaaldrich.com/product/sigma/sml1447#product-documentation
SML1447
Clemizole hydrochloride
≥98% (HPLC)
Synonym(s):
1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride, 1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole hydrochloride, 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride, CID 2782 hydrochloride, NSC 46261 hydrochloride
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $111.00 |
25 mg | Available to ship TODAYfromMILWAUKEE | $444.00 |
About This Item
Empirical Formula (Hill Notation):
C19H20ClN3 · HCl
CAS Number:
Molecular Weight:
362.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
214-605-4
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
ClC(C=C1)=CC=C1CN2C(CN3CCCC3)=NC4=CC=CC=C42.[H]Cl
InChI
1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
InChI key
DNFMJYXRIMLMBZ-UHFFFAOYSA-N
General description
Clemizole is a potent anti-allergic drug.
Biochem/physiol Actions
Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture.
Clemizole is a potent and preferring inhibitor of TRPC5; Antihistaminic.
Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment.[1]
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition desiccated | storage condition desiccated | storage condition - | storage condition desiccated |
| solubility H2O: 2 mg/mL, clear (warmed) | solubility H2O: ≥23 mg/mL | solubility DMSO: 1 mg/mL, clear (warmed) | solubility H2O: 2 mg/mL, clear (warmed) |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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In which solution clemizole will be dissolved ?
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