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Anti-KLOTHO antibody produced in rabbit

Name: Anti-KLOTHO antibody produced in rabbit
Brand: SIGMA
Price: 614 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-KL

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Size/SKU	Availability	Price
100 μg	Check Cart for Availability	$614.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

$614.00

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 111 kDa

species reactivity

human, mouse, rat

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

NP_004786

UniProt accession no.

Q9UEF7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KL(9365)

Description

General description

The gene KL (klotho) encodes a protein that has homology to β-glucosidase enzymes. The gene is mapped to human chromosome 13q12. The gene transcript spans a length of 5.2kb. Alternative splicing leads to the generation of two forms, a transmembrane and a secreted form. The transmembrane protein contains 1014 amino acids.

Immunogen

KLOTHO antibody was raised against a 16 amino acid peptide near the center of human KLOTHO.

Application

Anti-KL antibody produced in rabbit has been used as a primary antibody in immunoblot technique.[1]

Biochem/physiol Actions

The KL (klotho) gene is also referred to as an anti-aging gene as it encodes a senescence-related molecule. It regulates fibroblast growth factor (FGF) 23 signaling by functioning as a cofactor or coreceptor. It is involved in the activation of TRPV5 (transient receptor potential cation channel subfamily V member 5), an ion channel, by functioning as a glucuronidase. Klotho affects several intracellular signaling pathways, such as p53/p21, cAMP, protein kinase C (PKC) and Wnt signaling pathways. Mutations in this gene have been associated with premature aging-like phenotypes and shortened life span. Single nucleotide polymorphisms in this gene have been associated with priapism in sickle cell anaemia.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500604.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB2101270	SAB2501655	SAB2104815
Sigma-Aldrich SAB3500604 Anti-KLOTHO antibody produced in rabbit	Sigma-Aldrich SAB2101270 Anti-KL antibody produced in rabbit	Sigma-Aldrich SAB2501655 Anti-KL antibody produced in goat	Sigma-Aldrich SAB2104815 Anti-KL antibody produced in rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source goat	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
UniProt accession no. Q9UEF7	UniProt accession no. Q9UEF7	UniProt accession no. Q9UEF7	UniProt accession no. Q9UEF7
shipped in dry ice	shipped in wet ice	shipped in dry ice	shipped in wet ice

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c