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Anti-LIS1 antibody produced in rabbit

Name: Anti-LIS1 antibody produced in rabbit
Brand: SIGMA
Price: 584 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Lissencephaly 1, Anti-PAFAH, Anti-Platelet-activating factor acetylhydrolase

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Size/SKU	Availability	Price
100 μg	Check Cart for Availability	$584.00

About This Item

UNSPSC Code:

12352203

PubChem Substance ID:

329824640

NACRES:

NA.43

MDL number:

MFCD03457563

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), ICC, IF, WB

Citations:

$584.00

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

technique(s)

immunocytochemistry: suitable, immunofluorescence: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

P43034

UniProt accession no.

P43034

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

SMILES string

[P](=O)(OCC(O)COC(=O)CCCCCCC\C=C\C\C=C\CCCCC)(O)O

InChI

1S/C21H39O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h6-7,9-10,20,22H,2-5,8,11-19H2,1H3,(H2,24,25,26)/b7-6+,10-9+

InChI key

ZQTAMPRZFOOEEP-AVQMFFATSA-N

Gene Information

human ... PAFAH1B1(5048)

Description

General description

The gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1) encodes a protein named LIS1 (lissencephaly-1) that forms the α subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase (PAFAH). The gene is mapped to human chromosome 17p13.3.

Immunogen

LIS1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human LIS1.

Application

Monoclonal Anti-LIS1 antibody produced in mouse has been used in immunofluorescence.

Biochem/physiol Actions

The heterotrimeric enzyme, platelet-activating factor acteylhydrolase (PAFAH), catalyzes the cleavage of acetyl group at the SN-2 position of platelet-activating factor. The α subunit encoded by the gene PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1) interacts with tubulin and affects microtubule dynamics. Mutations in this gene have been linked to Miller–Dieker lissencephaly, a human brain malformation characterized by a smooth cerebral surface and a disordered organization of the cortical layers resulting from a defect in neuronal migration.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500302.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	SAB1404161	WH0005048M1	AP1170
Sigma-Aldrich SAB3500302 Anti-LIS1 antibody produced in rabbit	Sigma-Aldrich SAB1404161 Monoclonal Anti-PAFAH1B1, (N-terminal) antibody produced in mouse	Sigma-Aldrich WH0005048M1 Monoclonal Anti-PAFAH1B1 antibody produced in mouse	Sigma-Aldrich AP1170 Anti-PAFAH1B1 Mouse mAb (2C12)
description affinity isolated antibody, buffered aqueous solution	description clone 5A5, purified immunoglobulin, buffered aqueous solution	description clone 2C12, purified immunoglobulin, buffered aqueous solution	description liquid, clone 2C12, Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate -
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified antibody
biological source rabbit	biological source mouse	biological source mouse	biological source mouse
UniProt accession no. P43034	UniProt accession no. P43034	UniProt accession no. P43034	UniProt accession no. -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c