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Anti-ABIN3 antibody produced in rabbit

Name: Anti-ABIN3 antibody produced in rabbit
Brand: SIGMA
Price: 529 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-A20-binding inhibitor of NF-kappaB activation 3, Anti-LIND, Anti-Listeria-induced gene protein, Anti-TNFAIP3 interacting protein 3, Anti-TNIP3

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Size/SKU	Availability	Price
100 μg	Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)	$529.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IHC, WB

Citations:

$529.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

NP_079149

UniProt accession no.

Q96KP6

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNIP3(79931)

Description

General description

The nuclear factor NF-kB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.

Immunogen

ABIN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ABIN3.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500087.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	SAB3500007	SAB3500250	SAB3500491
Sigma-Aldrich SAB3500087 Anti-ABIN3 antibody produced in rabbit	Sigma-Aldrich SAB3500007 Anti-FNIP2 antibody produced in rabbit	Sigma-Aldrich SAB3500250 Anti-GATA3 antibody produced in rabbit	Sigma-Aldrich SAB3500491 Anti-RBBP8 antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... TNIP3(79931)	Gene Information human ... FNIP2(57600)	Gene Information human ... GATA3(2625)	Gene Information human ... RBBP8(5932)
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
UniProt accession no. Q96KP6	UniProt accession no. Q9P278	UniProt accession no. P23771	UniProt accession no. Q99708

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c