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Anti-Bcl-2 (ab1) antibody produced in rabbit

Name: Anti-Bcl-2 (ab1) antibody produced in rabbit
Brand: SIGMA
Price: 529 USD

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-B-cell CLL/lymphoma 2

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Pack Size	SKU	Availability	Price
100 μg		Check Cart for Availability	$529.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00239644

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

$529.00

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

P10415

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BCL2(596)

Description

General description

B-cell lymphoma 2 (BCL2), a proto-oncogene is made of three exons. It is widely expressed in immature B-cells and memory B cells. BCL2 is found at high levels in the thymus, spleen, and lymph nodes. BCL2 gene is mapped to human chromosome 18q21.33.

Immunogen

a peptide corresponding to 15 amino acids near the N-terminus of human Bcl-2.

Application

Anti-Bcl-2 (ab1) antibody produced in rabbit has been used in western blotting (1:100) (1:1000), immunohistochemistry (1:50), immunoprecipitation (IP) (1:1000)

Biochem/physiol Actions

B-cell lymphoma 2 (BCL2) plays a key role in maintaining the integrity of the mitochondrial membrane. It blocks the release of cytochrome C and its binding to apoptosis activating factor-1 (APAF1). BCL2 family proteins participate in modulating cell death. It also regulates apoptosis, necrosis, and autophagy. Upregulation of BCL2 is seen in several human cancers. Overexpression of BCL2 is observed in chronic lymphocytic leukemia (CLL), marginal cell lymphoma, and mantle cell lymphoma.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3335.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4500003	SAB4300339	AV01005
Sigma-Aldrich PRS3335 Anti-Bcl-2 (ab1) antibody produced in rabbit	Sigma-Aldrich SAB4500003 Anti-BCL-2 antibody produced in rabbit	Sigma-Aldrich SAB4300339 Anti-BCL2 (Ab-56) antibody produced in rabbit	Sigma-Aldrich AV01005 Anti-BCL2 antibody produced in rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
species reactivity human, mouse	species reactivity rat, mouse, human	species reactivity human	species reactivity human
technique(s) immunofluorescence: suitable, indirect ELISA: suitable, immunohistochemistry: suitable, western blot: suitable	technique(s) ELISA: 1:10000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000	technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000	technique(s) immunohistochemistry: suitable, western blot: suitable

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

33351804

33350404

3335-0404

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Global Trade Item Number

SKU	GTIN
SBP3335-0.05MG	04061832180083
PRS3335-100UG	04061832178745

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