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P3201

Platelet-Derived Growth Factor-BB human

≥98% (HPLC and SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

PDGF-BB

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10 μG

$576.00

50 μG

$1,490.00

$576.00

Estimated to ship onDecember 29, 2025Details

About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00213023

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Product Name

Platelet-Derived Growth Factor-BB human, PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC and SDS-PAGE)

form

lyophilized powder

potency

1.0-3.0 ng/mL EC50

quality

endotoxin tested

mol wt

~25 kDa

packaging

pkg of 10 μg
pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

UniProt accession no.

P01127

storage temp.

−20°C

Quality Level

200

Gene Information

human ... PDGFB(5155)

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P3326P8953P3076
Platelet-Derived Growth Factor-BB human PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

P3201

Platelet-Derived Growth Factor-BB human

Platelet-Derived Growth Factor-AB human PDGF-AB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

P3326

Platelet-Derived Growth Factor-AB human

Platelet-Derived Growth Factor from porcine platelets PDGF, lyophilized powder, suitable for cell culture

Sigma-Aldrich

P8953

Platelet-Derived Growth Factor from porcine platelets

Platelet-Derived Growth Factor-AA human PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

P3076

Platelet-Derived Growth Factor-AA human

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

-

recombinant

expressed in E. coli

assay

≥98% (HPLC and SDS-PAGE)

assay

≥97% (SDS-PAGE and N-terminal analysis)

assay

≥97% (SDS-PAGE and N-terminal analysis)

assay

≥98% (SDS-PAGE and HPLC)

biological source

human

biological source

human

biological source

Porcine

biological source

human

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Analysis Note

The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.

Application

Platelet-Derived Growth Factor-BB human has been used :
  • As a growth supplement in proximal tubule and glomerular explant cell culture[1]
  • In three-dimensional scaffold preparation[2]
  • To study the effect of brivanib on growth factor signaling pathways[3]
  • In transwell migration assay[4]

Biochem/physiol Actions

Platelet-derived growth factor (PDGF) elicits multifunctional actions with a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells, and chondrocytes.[5] PDGF significantly activates chemotaxis of neutrophils, monocytes, and fibroblasts.[6][5] It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins, and modulates LDL (low density lipoprotein) receptor binding.
PDGF stimulates fibroblast proliferation and extracellular matrix production in order to facilitate tissue repair.[7] PDGF-BB isomer is found to be critical in angiogenesis and is highly expressed in tumor, mediating oncogenic pericyte recruitment.[8] PDGF-BB is an important regulator of bone homeostasis, repair and regeneration.[9]

General description

Platelet-derived growth factor (PDGF) is expressed as homo and heterodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD.[8] The PDGF gene is highly conserved mapped to human chromosome 7p22.3.[10][11] The active form of Pdgf exists as disulfide-linked dimers. It consists of cystine-knot-fold growth factor domain, which is highly conserved, except for the N-terminal prodomain, which shows variation in length among the isoforms.[12]

Other Notes

Dimer of the B chain of human PDGF.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30 mM acetic acid.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000513041
0000513041
0000482676
0000482676
0000459717

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Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts
Antoniades HN
Proceedings of the National Academy of Sciences of the USA, 88.2, 565-569 (1991)
Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling.
Nakamura I, et al.
PLoS ONE, 9.4 (2014)
Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury.
Szczypka MS, et al.
Stem Cells, 23.1, 44-54 (2005)
Clinical Findings Associated with a De Novo Partial Trisomy 10p11. 22p15. 3 and Monosomy 7p22. 3 Detected by Chromosomal Microarray Analysis.
Kohannim O,et al.
Case Reports in Genetics, 2011 , 1-6 (2011)
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Shima AHR, et al.
Proceedings of the National Academy of Sciences of the USA, 107.25, 11307-11312 (2010)
View All Related Papers

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Data Sheet - P3201

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