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MilliporeSigma

P0781

Penicillin-Streptomycin

liquid, non-animal origin, suitable for cell culture, BioReagent

Synonym(s):

Pen-Strep

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20 ML

$25.80

50 ML

$35.50

100 ML

$47.10

$25.80


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About This Item

UNSPSC Code:
12352207
PubChem Substance ID:
NACRES:
NA.76

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Product Name

Penicillin-Streptomycin, with 10,000 units penicillin and 10 mg streptomycin per mL in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture

SMILES string

CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O.CNC[C@H]4[C@H](O)[C@@H](O)[C@H](CCO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)C5(O)C=O)O[C@H]6[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]6NC(N)=N

InChI

1S/C23H43N7O12.C16H18N2O4S/c1-7-23(38,6-32)18(42-19-8(5-28-2)12(33)13(34)9(40-19)3-4-31)20(39-7)41-17-11(30-22(26)27)14(35)10(29-21(24)25)15(36)16(17)37;1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h6-20,28,31,33-38H,3-5H2,1-2H3,(H4,24,25,29)(H4,26,27,30);3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t7-,8-,9-,10+,11-,12-,13-,14+,15-,16+,17+,18-,19-,20-,23+;11-,12+,14-/m01/s1

InChI key

KMOOCZWLFBSQCW-XFOLRDBHSA-N

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

concentration

100 ×

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes
protein synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

Quality Level

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1 of 4

This Item
P4333P445811074440001
antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes, cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes, protein synthesis | interferes

mode of action

cell wall synthesis | interferes, protein synthesis | interferes

mode of action

cell wall synthesis | interferes, protein synthesis | interferes

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

100

product line

BioReagent

product line

BioReagent

product line

BioReagent

product line

-

form

liquid

form

liquid

form

liquid

form

lyophilized (clear, colorless solution after reconstitution)

Application

Penicillin-Streptomycin solution is used to supplement cell culture media to control bacterial contamination.[1][2][3] It has also been used for the preparation of lipid emulsions.[4] It is recommended for use in cell culture applications at 10 mL/L.

General description

Penicillin streptomycin, also known as Pen-Strep, is the most commonly used antibiotic solution for culture of mammalian cells. Penicillin Streptomycin solution is used to maintain sterile conditions during cell culture, and they show few adverse effects on the cultured cells.[5][6]

Other Notes

20x100ml,20ml,100ml
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
This product is formulated to contain 10,000 units penicillin and 10 mg streptomycin/mL.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Bryan Brown et al.
Tissue engineering, 12(3), 519-526 (2006-04-04)
The extracellular matrix (ECM) has been successfully used as a scaffold for constructive remodeling of multiple tissues in both preclinical studies and in human clinical applications. The basement membrane is a specialized form of the ECM that supports and facilitates
D T Stein et al.
The Journal of clinical investigation, 100(2), 398-403 (1997-07-15)
Lowering of the elevated plasma FFA concentration in 18- 24-h fasted rats with nicotinic acid (NA) caused complete ablation of subsequent glucose-stimulated insulin secretion (GSIS). Although the effect of NA was reversed when the fasting level of total FFA was
Tinh-Hai Collet et al.
Molecular metabolism, 6(10), 1321-1329 (2017-10-17)
Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese individuals with complete POMC deficiency.
184: Toxic effects of antibiotics routinely used in cell culture on primary cultures of dissociated mouse brain cells.
Amonn F
Pediatric Research, 10(10), 900-900 (1976)
Zijin Zhou et al.
International journal of food microbiology, 257, 176-182 (2017-07-03)
The efficacy of levulinic acid (LVA) in combination with sodium dodecyl sulfate (SDS) in removal of foodborne viruses, enteric bacterial pathogens and their surrogates on fresh strawberries was investigated. Inoculated strawberries were treated with potable water, sodium hypochlorite solution (50ppm)

Questions

1–2 of 2 Questions  
  1. Hello, Does the Pen Strep (P0781) contain any calcium in its formulation? Thank you!

    1 answer
    1. This product is not tested for the presence of calcium. However, the solution contains Streptomycin sulfate and Penicillin G sodium in 0.9% Sodium chloride. No calcium-containing components are used in the preparation of this material.

      Helpful?

  2. What is the storage temperature and the stability of the Penicillin-Streptomycin solution?

    1 answer
    1. This product is stored at -20°C and is assigned an expiration date of approximately 3 years from the date of Quality Release. Upon thawing, the solution may be aliquoted and refrozen one time for long term storage, up to the lot specific expiration date. The thawed solution is stable for up to 1 week if stored refrigerated and up to 3 days in culture medium at 37°C

      Helpful?

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