I9890

m-Iodobenzylguanidine hemisulfate salt

Name: <I>m</I>-Iodobenzylguanidine hemisulfate salt
Brand: SIGMA
Price: 182 CAD

≥98% (HPLC and TLC), ADP ribosylation inhibitor

Synonym(s):

MIBG

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About This Item

Linear Formula:

C₈H₁₀IN₃ · 1/2H₂SO₄

CAS Number:

87862-25-7

Molecular Weight:

324.13

UNSPSC Code:

12352200

PubChem Substance ID:

24278499

NACRES:

NA.77

MDL number:

MFCD00151189

Key Documents

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Product Name

m-Iodobenzylguanidine hemisulfate salt, ≥98% (HPLC and TLC)

SMILES string

OS(O)(=O)=O.NC(=N)NCc1cccc(I)c1.NC(=N)NCc2cccc(I)c2

InChI

1S/2C8H10IN3.H2O4S/c2*9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h2*1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4)

InChI key

XNACDNPGABUBFR-UHFFFAOYSA-N

assay

≥98% (HPLC and TLC)

impurities

<0.5% Free iodobenzylamine

storage temp.

2-8°C

Quality Level

200

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Bioactive Small Molecule Inhibitors

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Show Differences

1 of 4

This Item	B1155	SML0962	N9653
Sigma-Aldrich I9890 m-Iodobenzylguanidine hemisulfate salt	Sigma-Aldrich B1155 bisBenzimide H 33258	Sigma-Aldrich SML0962 M-110	Sigma-Aldrich N9653 Netropsin dihydrochloride
assay ≥98% (HPLC and TLC)	assay ≥98% (HPLC and TLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC and TLC)
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
impurities <0.5% Free iodobenzylamine	impurities -	impurities -	impurities -

Biochem/physiol Actions

Antitumor agent which inhibits ADP ribosylation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000480175

0000439784

0000417147

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Cytotoxic and antitumor effects of the norepinephrine analogue meta-iodo-benzylguanidine (MIBG).

L A Smets et al.

Cancer chemotherapy and pharmacology, 21(1), 9-13 (1988-01-01)

Meta-iodo-benzylguanidine (MIBG) is an analogue of the neurotransmitter norepinephrine. In its radioiodinated form, MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. The potential cytotoxicity of the unlabeled drug was tested. MIBG appeared

Potential diagnostic value of regional myocardial adrenergic imaging using (123)I-MIBG SPECT to identify patients with Lewy body diseases.

Adrien Lebasnier et al.

European journal of nuclear medicine and molecular imaging, 42(7), 1043-1051 (2015-01-30)

The aim of this study was to determine the potential diagnostic value of regional myocardial adrenergic (123)I-metaiodobenzylguanidine (MIBG) single photon emission computed tomography (SPECT) imaging to identify patients with Lewy body diseases (LBD+). Sixty-four consecutive patients who underwent cardiac (123)I-MIBG

Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography.

Yunlong Zan et al.

Molecular imaging, 14, 373-384 (2015-07-15)

The objective of this work was to evaluate the sympathetic nervous system and structure remodeling during the progression of heart failure in a rodent model using dynamic cardiac single-photon emission computed tomography (SPECT). The spontaneously hypertensive rat (SHR) model was

Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma.

Steven G DuBois et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 21(12), 2715-2721 (2015-02-20)

(131)I-metaiodobenzylguanidine (MIBG) is a radiopharmaceutical with activity in neuroblastoma. Vorinostat is a histone deacetylase inhibitor that has radiosensitizing properties. The goal of this phase I study was to determine the MTDs of vorinostat and MIBG in combination. Patients ≤ 30

Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation).

C Loesberg et al.

Biochimica et biophysica acta, 1037(1), 92-99 (1990-01-19)

Meta-iodobenzylguanidine (MIBG) is a guanidine analogue of the neurotransmitter norepinephrine. Radioiodinated [131I]MIBG is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Moreover, non-radiolabelled MIBG exerts several cell-biological effects, tentatively ascribed to interference with cellular

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m-Iodobenzylguanidine hemisulfate salt