Seladin-1 (selective Alzheimer′s disease indicator-1) is an anti-apoptotic gene. It is a human homolog of the Diminuto/Dwarf1 gene described in plants andC. elegans. Seladin-1 is encoded by the DHCR24 (3-b-hydroxysterol-D-24-reductase) gene, a flavin-adenine-dinucleotide (FAD)-dependent oxidoreductase. It is mainly located in the endoplasmic reticulum.
Immunogen
synthetic peptide corresponding to amino acids 68-85 of human seladin-1, conjugated to KLH.
Application
Anti-Seladin-1 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Seladin-1 (selective Alzheimer′s disease indicator-1) catalyzes the conversion of desmosterol to cholesterol. It prevents apoptosis via inhibition of caspase-3, a key mediator of the apoptotic cascade, suggesting that seladin-1 may be involved in the regulation of cell survival and death. Decreased expression of seladin-1 in specific neurons is linked to Alzheimer′s disease (AD). Seladin-1 functions as a key mediator of Ras-induced senescence in mouse and human fibroblasts. It protects neurons from β-amyloid toxicity and oxidative stress. Seladin-1 is involved in cholesterol homeostasis.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(19), 7345-7352 (2000-09-29)
In Alzheimer's disease (AD) brains, selected populations of neurons degenerate heavily, whereas others are frequently spared from degeneration. To address the cellular basis for this selective vulnerability of neurons in distinct brain regions, we compared gene expression between the severely
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
