Skip to Content
MilliporeSigma
All Photos(1)

Documents

PZ0312

Sigma-Aldrich

(S)-PFI-2

Synonym(s):

(S)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride, (S)-PFI-2 hydrochloride, PF-06477717 hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C23H25F4N3O3S · HCl
CAS Number:
1627607-88-8
Molecular Weight:
535.98
UNSPSC Code:
12352200
PubChem Substance ID:
329823832
NACRES:
NA.77

assay

≥98% (HPLC)

Quality Level

100

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[H]Cl.O=C(N1CCCC1)[C@H](CC2=CC=CC(C(F)(F)F)=C2)NS(C3=CC4=C(C(F)=C3)CNCC4)(=O)=O

InChI

1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27;/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2;1H/t21-;/m0./s1

InChI key

ZADKZNVAJGEFLC-BOXHHOBZSA-N

Related Categories

General description

(S)-PFI-2 is a negative control enantiomer and a biotinylated derivative of (R)-PFI-2, which helps to study the biological activity of SETD7 (SET domain containing (lysine methyltransferase) 7).

Biochem/physiol Actions

(S)-PFI-2 is the negative control probe for (R)-PFI-2 hydrochloride, which is a histone-lysine N-methyltransferase (HKMT) inhibitor selective for SETD7 (SET9). (R)-PFI-2 has 1000-fold selectivity for SETD7 (SET9) over other methyltransferases and other non-epigenetic targets and an IC50 value of 2 nM. (S)-PFI-2 is 500-fold less active.

For characterization details of (R)-PFI-2 and (S)-PFI-2, please visit the PFI-2 probe summary on the Structural Genomics Consortium (SGC) website.

(R)-PFI-2, the active SETD7 probe, is available from Sigma. To learn more about and purchase (R)-PFI-2, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

(S)-PFI-2 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

related product

Product No.
Description
Pricing

U4885

UNC0638 hydrate, ≥98% (HPLC)

SML0067

IOX1, ≥97% (HPLC)

SML0352

PFI-1, ≥98% (HPLC)

SML0652

IOX2, ≥98% (HPLC)

SML0662

UNC1215, ≥98% (HPLC)

SML0701

GSK-J4, ≥98% (HPLC)

SML0709

GSK-J1, ≥98% (HPLC)

SML0768

GSK2801, ≥98% (HPLC)

SML0766

GSK343, ≥98% (HPLC)

SML0778

UNC1999, ≥98% (HPLC)

SML0974

(+/-)-JQ1, ≥98% (HPLC)

SML0992

Bromosporine, ≥98% (HPLC)

SML0939

PFI-3, ≥98% (HPLC)

SML1037

UNC0642, ≥98% (HPLC)

SML1072

GSK-LSD1, ≥98% (HPLC)

SML1107

SGC0946, ≥98% (HPLC)

SML1133

SGC-CBP30, ≥98% (HPLC)

SML1134

I-CBP112, ≥98% (HPLC)

SML1184

OF-1, ≥98% (HPLC)

SML1209

OICR-9429, ≥98% (HPLC)

SML1242

SGC707, ≥98% (HPLC)

SML1279

LLY-507, ≥97% (HPLC)

SML1276

BAZ2-ICR, ≥98% (HPLC)

PZ0307

PFI-4, ≥98% (HPLC)

SML1408

(R)-PFI-2, ≥97% (HPLC)

SML1410

A-366, ≥98% (HPLC)

SML1486

NI-57, ≥98% (HPLC)

SML1534

I-BRD9, ≥98% (HPLC)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Dalia Barsyte-Lovejoy et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(35), 12853-12858 (2014-08-20)
SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple signaling and disease related pathways with a broad diversity of reported substrates. Here, we report the discovery of (R)-PFI-2-a first-in-class, potent (Ki (app) = 0.33 nM), selective, and cell-active

Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service