HPA019095

Anti-METAP2 antibody produced in rabbit

Name: Anti-METAP2 antibody produced in rabbit
Brand: SIGMA
Price: 881 CAD

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonyme(s) :

Anti-Initiation factor 2-associated 67 kDa glycoprotein, Anti-MAP 2, Anti-MetAP 2, Anti-Methionine aminopeptidase 2, Anti-Peptidase M 2, Anti-p67, Anti-p67eIF2

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100 μL

881,00 $

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A propos de cet article

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02096868

Human Protein Atlas Number:

HPA019095

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IHC

Citations:

Principaux documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

RNAi knockdown
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:1000-1:2500

immunogen sequence

SGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKK

UniProt accession no.

P50579

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... METAP2(10988)

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Enhanced Validation Antibodies

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Cet article	HPA037997	HPA021069	HPA001341
Sigma-Aldrich HPA019095 Anti-METAP2 antibody produced in rabbit	Sigma-Aldrich HPA037997 Anti-METAP1 antibody produced in rabbit	Sigma-Aldrich HPA021069 Anti-TPP2 antibody produced in rabbit	Sigma-Aldrich HPA001341 Anti-MECP2 antibody produced in rabbit
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
product line Prestige Antibodies^® Powered by Atlas Antibodies	product line -	product line Prestige Antibodies^® Powered by Atlas Antibodies	product line Prestige Antibodies^® Powered by Atlas Antibodies
technique(s) immunoblotting: 0.04-0.4 μg/mL, immunohistochemistry: 1:1000-1:2500, immunofluorescence: 0.25-2 μg/mL	technique(s) immunohistochemistry: 1:200-1:500	technique(s) immunoblotting: 0.04-0.4 μg/mL, immunohistochemistry: 1:50-1:200	technique(s) immunohistochemistry: 1:200- 1:500

General description

The gene METAP2 (methionine aminopeptidase 2) is mapped to human chromosome 12q22. The protein localizes in the cytoplasm.

Immunogen

Methionine aminopeptidase 2 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Methionine aminopeptidases (METAPs) are responsible for removal of methionine from newly generated polypeptides. Glycosylated METAP2 protects eIF2α (eukaryotic translation initiation factor 2 subunit α) from EIF2AK (eIF2 kinase)-mediated phosphorylation, thereby promoting protein synthesis. It has been shown to play crucial role in tumorigenesis. METAP2 is a target of the fungal metabolite fumagillin.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Other Notes

Corresponding Antigen APREST74783

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

R10816

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Localization and function of a eukaryotic-initiation-factor-2-associated 67-kDa glycoprotein.

Shiyong Wu

World journal of biological chemistry, 1(10), 313-320 (2011-05-04)

To study the localization and function of a eukaryotic initiation factor 2 (eIF2α)-associated 67-kDa glycoprotein (p67). Immunofluorescence staining, (35)S-Met/Cys metabolic labeling, Western blotting analysis, sucrose gradient centrifugation and high speed centrifugation were used to determine the localization of proteins in

Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.

L A Tucker et al.

Oncogene, 27(28), 3967-3976 (2008-02-12)

Methionine aminopeptidase-2 (MetAP2) processes N-terminal methionine from nascent cellular proteins. Inhibition of MetAP2 has been shown to block angiogenesis and suppress tumor growth in preclinical tumor models. However, the biological role of MetAP2 in cancer is not well understood. We

Structure of human methionine aminopeptidase-2 complexed with fumagillin.

S Liu et al.

Science (New York, N.Y.), 282(5392), 1324-1327 (1998-11-13)

The fungal metabolite fumagillin suppresses the formation of new blood vessels, and a fumagillin analog is currently in clinical trials as an anticancer agent. The molecular target of fumagillin is methionine aminopeptidase-2 (MetAP-2). A 1.8 A resolution crystal structure of

Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with changes in transcriptional profiles.

Laura Mosca et al.

American journal of hematology, 88(1), 16-23 (2012-10-10)

Primary plasma cell leukemia (pPCL) is a rare, yet aggressive form of de novo plasma cell tumor, distinct from secondary PCL (sPCL) which represents a leukemic transformation of pre-existing multiple myeloma (MM). Herein, we performed a comprehensive molecular analysis of

Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases.

Qing Xiao et al.

Biochemistry, 49(26), 5588-5599 (2010-06-05)

Methionine aminopeptidase (MetAP) catalyzes the hydrolytic cleavage of the N-terminal methionine from newly synthesized polypeptides. The extent of removal of methionyl from a protein is dictated by its N-terminal peptide sequence. Earlier studies revealed that MetAPs require amino acids containing

Numéro d'article de commerce international

Référence	GTIN
HPA019095-100UL	04061836312527
HPA019095-25UL	04061842866977

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