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H1791

Anti-HOXC8 antibody produced in rabbit

Name: Anti-HOXC8 antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-HOX3A, Anti-Homeobox 3A, Anti-Homeobox C8, Anti-Hox-3.1 (mouse)

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IP, WB

Citations:

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~34 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXC8, western blot: 1-2 μg/mL using extracts of HEK-293T cells over expressing human HOXC8

UniProt accession no.

P31273

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HOXC8(3224)
mouse ... Hoxc8(15426)
rat ... Hoxc8(24460)

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General description

Homeobox C8 (HOXC8) is a member of homeobox (HOX) family. It is a transcription factor, expressed in neural tube, brain, breast and adult bone marrow. HOX genes consist of a highly conserved 60-amino-acid region (the homeobox) with DNA-binding activity, that contributes to their activity as transcription factors. The gene is located on human chromosome 12q13.

Immunogen

synthetic peptide corresponding to amino acids 96-110 of human HOXC8 conjugated to KLH. The corresponding sequence is identical in mouse and rat.

Application

Anti-HOXC8 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

Homeobox C8 (HOXC8) is involved in cell growth, migration and metastasis of various cancers. Hox genes are important for embryonic development. Mutations in this gene are implicated in the development of cancers, such as leukemias or neoplasms of the breast, prostate, kidney, colon, skin and brain.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Lot/Batch Number

117M4896

059K4770

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HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.

Mansi Shah et al.

Molecular cancer, 16(1), 38-38 (2017-02-17)

Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissues. Here, we screened the expression of homeobox

MiR-148a-3p may contribute to flawed decidualization in recurrent implantation failure by modulating HOXC8.

Qian Zhang et al.

Journal of assisted reproduction and genetics, 37(10), 2535-2544 (2020-08-11)

To evaluate whether miR-148a-3p overexpression is associated with disrupted decidualization of recurrent implantation failure (RIF). Endometrial miRNA and mRNA expression profiles during the implantation window derived from women with and without RIF were identified using microarray and RT-qPCR. Immortalized human

Embigin, regulated by HOXC8, plays a suppressive role in breast tumorigenesis

Chao F, et al.

Oncotarget, 6(27), 23496-23496 (2015)

Overexpression of HOXC8 is associated with poor prognosis in epithelial ovarian cancer

Lu S, et al.

Reproductive Sciences, 23(7), 944-954 (2016)

The predictive potential and oncogenic effects of HOXC8 expression on osteosarcoma

Cheng L, et al.

Tumor Biology, 37(11), 14961-14967 (2016)

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Global Trade Item Number

SKU	GTIN
H1791-200UL	04061837771927
H1791-25UL	04061837771934

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