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MilliporeSigma

484407

1-Methoxy-2-propanol

greener alternative

≥99.5%

Synonym(s):

Propylene glycol methyl ether, Propyleneglycol monomethyl ether

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$74.60

2.5 L

$159.00

4 L

$216.00

18 L

$634.00

$74.60

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About This Item

Linear Formula:
CH3CH(OH)CH2OCH3
CAS Number:
107-98-2
Molecular Weight:
90.12
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
57651153
EC Number:
203-539-1
Beilstein/REAXYS Number:
1731270
MDL number:
MFCD00004537
Assay:
≥99.5%
Application(s):
microbiology
Bp:
118-119 °C (lit.)
Vapor pressure:
10.9 mmHg ( 25 °C)

Key Documents

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Product Name

1-Methoxy-2-propanol, ≥99.5%

assay

≥99.5%

form

liquid

InChI key

ARXJGSRGQADJSQ-UHFFFAOYSA-N

InChI

1S/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3

SMILES string

CC(O)COC

vapor density

3.12 (vs air)

vapor pressure

10.9 mmHg ( 25 °C)

product line

ReagentPlus®

autoignition temp.

532 °F

expl. lim.

13.8 %

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

impurities

≤0.001% water

refractive index

n20/D 1.403 (lit.)

bp

118-119 °C (lit.)

mp

-97 °C

solubility

water: miscible

density

0.916 g/mL at 25 °C (lit.)

application(s)

microbiology

greener alternative category

, Aligned

Quality Level

200

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General description

1-Methoxy-2-propanol (Propylene glycol methyl ether, PGME), a glycol ether, can be synthesized by reacting propylene oxide with methanol in the presence of ZnMgAl (zinc-magnesium-aluminium) catalysts.[1] Its degradation by microorganisms in different soil types has been investigated.[2] An oral reference dose (RfD) and an inhalation reference concentration (RfC) values of PGME have been obtained from inhalation studies in F344 rats and B6C3F1 mice.[3]
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Monoethers, especially propylene glycol methyl ether (PGME), are widely used as pollution-free solvents in fine chemical synthesis in pharmaceutical, chemical and cosmetic industries and thus aligns with "Safer Solvents and Auxiliaries". Click here for more information.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

hcodes

H226,H336

Hazard Classifications

Flam. Liq. 3 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

88.7 °F - closed cup - (External MSDS)

flash_point_c

31.5 °C - closed cup - (External MSDS)

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB6317
MKCZ6179
SDBB4845
SDBB2694
STBL4198

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Influence of acid-base properties of ZnMgAl-mixed oxides for the synthesis of 1-methoxy-2-propanol.
Cheng W, et al.
Applied Clay Science, 42(1), 111-115 (2008)
Juergen Brieger et al.
Toxicology letters, 177(2), 138-143 (2008-02-26)
To evaluate the impact of 1-methoxypropanol-2 (MEP) for the stimulation of an inflammatory response in human respiratory mucosa, we exposed 22 primary cell cultures of nasal respiratory epithelia of healthy individuals to MEP concentrations at the level of the German
S R Vink et al.
Regulatory toxicology and pharmacology : RTP, 58(1), 64-71 (2010-04-17)
REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in
Catherine Tomicic et al.
Analytical and bioanalytical chemistry, 396(7), 2709-2714 (2010-02-16)
Glycol ethers still continue to be a workplace hazard due to their important use on an industrial scale. Currently, chronic occupational exposures to low levels of xenobiotics become increasingly relevant. Thus, sensitive analytical methods for detecting biomarkers of exposure are
W R Berendsen et al.
Biotechnology and bioengineering, 95(5), 883-892 (2006-08-29)
Lipase-catalyzed kinetic resolution of racemates is a popular method for synthesis of chiral synthons. Most of these resolutions are reversible equilibrium limited reactions. For the first time, an extensive kinetic model is proposed for kinetic resolution reactions, which takes into
View All Related Papers

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Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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