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917710

A1V1PF2-OEt

≥95%

Promotion Available

Synonym(s):

AVP ligand, Ethyl (S)-2-((S)-1-((S)-2-((S)-2-aminopropanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoate, IAP E3 ligase lead for protein degrader research, SNIPER building block

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Size/SKUAvailabilityPrice
100 mg

Available to ship TODAYfromMILWAUKEE

$517.00

About This Item

Empirical Formula (Hill Notation):
C25H37FN4O5
Molecular Weight:
492.58
MDL number:
UNSPSC Code:
41116105
NACRES:
NA.22

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ligand

A1V1PF2

Quality Segment

assay

≥95%

form

powder

reaction suitability

reagent type: ligand

functional group

amine

storage temp.

2-8°C

SMILES string

N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O)C

InChI key

VMRCYJZQDCYTJO-MVJPYGJCSA-N

Application

A1V1PF2-OEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V1PF2-OEt is also available as BocA1V1PF2 (917478).

A1V1PF2-OEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here: Browse our full synthesis offering here for streamlining SNIPER and PROTAC® degrader libraries: Degrader Building Blocks

917427 A1V1PF2-OEt-C6-NH2 hydrochloride
917672 A1V1PF2-OEt-C10-NH2 hydrochloride
917923 A1V1PF2-OEt-PEG1-NH2 hydrochloride
916676 A1V1PF2-OEt-PEG3-NH2 hydrochloride

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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This Item
917478917222916978
description

≥95%

description

≥95%

description

≥95%

description

≥95%

reaction suitability

reagent type: ligand

reaction suitability

reagent type: ligand

reaction suitability

reagent type: ligand

reaction suitability

reagent type: ligand

assay

≥95%

assay

≥95%

assay

≥95%

assay

≥95%

functional group

amine

functional group

carboxylic acid

functional group

amine

functional group

carboxylic acid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

form

powder

form

powder

form

powder

form

powder


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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