BocA1V1PF2-OPEG₃-NH₂ hydrochloride

Name: BocA1V1PF2-OPEG<SUB>3</SUB>-NH<SUB>2</SUB> hydrochloride
Brand: ALDRICH
Price: 3676 BRL

Sinônimo(s):

2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl (S)-2-((S)-1-((S)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoate hydrochloride, AVP conjugate for IAP-mediated protein degrader development, SNIPER building block

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50 MG

R$ 3.676,00

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Sobre este item

Fórmula empírica (Notação de Hill):

C₃₆H₅₈FN₅O₁₀ · xHCl

Peso molecular:

739.87 (free base basis)

MDL number:

MFCD34166210

UNSPSC Code:

41116105

NACRES:

NA.22

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ligand

BocA1V1PF2

Quality Level

100

form

powder

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

functional group

amine

storage temp.

2-8°C

SMILES string

C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCCOCCOCCOCCN)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O.Cl

InChI key

MLZXIXXBYKGHGE-ZRWAWTQBSA-N

Categorias relacionadas

Chemical Biology

Protein Degrader Building Blocks

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Este Item	917435	916927	917184
Sigma-Aldrich 917680 BocA1V1PF2-OPEG₃-NH₂ hydrochloride	Sigma-Aldrich 917435 BocA1V1PF2-OPEG₁-NH₂hydrochloride	Sigma-Aldrich 916927 BocA1V1PF2-OC₆-NH₂ hydrochloride	Sigma-Aldrich 917184 BocA1V1PF2-OC₁₀-NH₂ hydrochloride
functional group amine	functional group amine	functional group amine	functional group amine
reaction suitability reactivity: carboxyl reactive, reagent type: ligand-linker conjugate	reaction suitability reactivity: carboxyl reactive, reagent type: ligand-linker conjugate	reaction suitability reactivity: carboxyl reactive, reagent type: ligand-linker conjugate	reaction suitability reactivity: carboxyl reactive, reagent type: ligand-linker conjugate
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
form powder	form powder	form powder	form powder
ligand BocA1V1PF2	ligand BocA1V1PF2	ligand BocA1V1PF2	ligand BocA1V1PF2

Application

Protein degrader building block BocA1V1PF2-OPEG₃-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and SNIPER (specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers) technology. Developed in partnership with ComInnex, this conjugate contains an in silico-derived IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with an acid on a target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and protein degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, including CRBN and VHL targeted, parallel synthesis can be used to more quickly generate SNIPER and PROTAC^® degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight.

Building blocks in this series:
917478 BocA1V1PF2
916927 BocA1V1PF2-OC₆-NH₂ hydrochloride
917184 BocA1V1PF2-OC₁₀-NH₂ hydrochloride
917435 BocA1V1PF2-OPEG₁-NH₂ hydrochloride
917680 BocA1V1PF2-OPEG₃-NH₂ hydrochloride

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands.

Other Notes

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs—Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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BocA1V2PF1-NHC₁₀-NH₂

917435

BocA1V1PF2-OPEG₁-NH₂hydrochloride, ≥95%

916978

BocA1V2PF1, ≥95%

917699

BocA1V2PF2-NHC₁₀-NH₂, ≥85%

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BocA1V2PF2-NHPEG₁-NH₂

916714

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917192

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916935

A1V2PF2-NHEt-PEG₁-NH₂

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CCW16-PEG₃-BocNH, ≥95%

CIX001

ComInnex IAP Ligand Library

Classe de armazenamento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análise (COA)

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SNIPERs-Hijacking IAP activity to induce protein degradation.

Mikihiko Naito et al.

Drug discovery today. Technologies, 31, 35-42 (2019-06-16)

The induction of protein degradation by chimeric small molecules represented by proteolysis-targeting chimeras (PROTACs) is an emerging approach for novel drug development. We have developed a series of chimeric molecules termed specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein

Nobumichi Ohoka et al.

The Journal of biological chemistry, 292(11), 4556-4570 (2017-02-06)

Many diseases, especially cancers, result from aberrant or overexpression of pathogenic proteins. Specific inhibitors against these proteins have shown remarkable therapeutic effects, but these are limited mainly to enzymes. An alternative approach that may have utility in drug development relies

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.

Tasuku Ishida et al.

SLAS discovery : advancing life sciences R & D, 26(4), 484-502 (2020-11-05)

Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are a new modality of chemical tools and potential therapeutics to understand and treat human disease. A required PROTAC component is a ligand binding to an E3 ubiquitin ligase, which is then joined to another ligand binding to a protein to

Artigos

Accelerating Protein Degrader Discovery with IAP

Plate of 80 ligands against E3 ligase IAP designed by ComInnex; allows creation of bifunctional targeted protein degraders or molecular glues.

Degrader Building Blocks with IAP In Silico-Derived Ligands

Targeted protein degradation reduces disease-relevant proteins in cells using small molecules, hijacking endogenous proteolysis systems.

Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

Targeted protein degradation (TPD) is an emerging strategy that uses small molecules to hijack endogenous proteolysis systems to degrade disease-relevant proteins and thus reduce their abundance in cells.

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Número de item de comércio global

SKU	GTIN
917680-50MG	04061842647729

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BocA1V1PF2-OPEG3-NH2 hydrochloride