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741825

XPhos Pd G2

98%, solid

Synonym(s):

2nd Generation XPhos Precatalyst, Chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II), X-Phos aminobiphenyl palladium chloride precatalyst, XPhos-Pd-G2

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Size/SKUAvailabilityPrice
250 mg

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$49.60
1 g

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$156.00
5 g

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$557.00
10 g

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$1,070.00
25 g

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$2,070.00
100 g

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$6,740.00
500 g

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$18,940.00

About This Item

Empirical Formula (Hill Notation):
C45H59ClNPPd
CAS Number:
Molecular Weight:
786.80
UNSPSC Code:
12161600
PubChem Substance ID:
NACRES:
NA.22

$49.60


Estimated to ship onSeptember 08, 2026Details


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Product Name

XPhos Pd G2, 98%

Quality Segment

product line

Buchwald precatalyst Generation 2

assay

98%

form

solid

feature

generation 2

reaction suitability

core: palladium, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst
reaction type: Cross Couplings

mp

202-210 °C

functional group

phosphine

SMILES string

Nc1ccccc1-c2ccccc2[Pd]Cl.Nc3ccccc3-c4ccccc4[Pd]Cl.CC(C)c5cc(C(C)C)c(-c6cccc(c6)P(C7CCCCC7)C8CCCCC8)c(c5)C(C)C.CC(C)c9cc(C(C)C)c(c(c9)C(C)C)-c%10ccccc%10P(C%11CCCCC%11)C%12CCCCC%12

InChI

1S/2C33H49P.2C12H10N.2ClH.2Pd/c1-23(2)27-21-31(24(3)4)33(32(22-27)25(5)6)26-14-13-19-30(20-26)34(28-15-9-7-10-16-28)29-17-11-8-12-18-29;1-23(2)26-21-30(24(3)4)33(31(22-26)25(5)6)29-19-13-14-20-32(29)34(27-15-9-7-10-16-27)28-17-11-8-12-18-28;2*13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;;;;/h13-14,19-25,28-29H,7-12,15-18H2,1-6H3;13-14,19-25,27-28H,7-12,15-18H2,1-6H3;2*1-6,8-9H,13H2;2*1H;;/q;;;;;;2*+1/p-2

InChI key

HMRJFNBZAWHTGN-UHFFFAOYSA-L

General description

XPhos Pd G2 is a bulky monodentate biaryl ligand. It is a Buchwald′s 2nd generation preformed catalyst. It undergoes rapid reductive elimination to form a reactive, monoligated Pd(0) species.

Application

XPhos Pd G2 was employed as catalyst in the following reactions:
  • Palladium-catalyzed Suzuki-Miyaura coupling reactions of potassium organotrifluoroborates and sulfamates.
  • Suzuki-Miyaura cross-coupling reactions of sensitive aryl and heteroarylboronic acids.
  • Synthesis of potassium Boc-protected secondary aminomethyltrifluoroborates, via Suzuki-Miyaura cross-coupling reaction.
For small scale and high throughput uses, product is also available as ChemBeads (927775)
2nd Generation Buchwald Precatalysts

  • Widely used for Suzuki-Miyaura cross-coupling reactions

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This Item
763381753009763012
description

98%

description

98%, 1:1 MTBE adduct

description

-

description

95%

reaction suitability

reaction type: Sonogashira Coupling, reaction type: Heck Reaction, reaction type: Negishi Coupling, reaction type: Suzuki-Miyaura Coupling, core: palladium, reaction type: Stille Coupling, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reagent type: catalyst
reaction type: Cross Couplings, reaction type: Hiyama Coupling

reaction suitability

core: palladium, reaction type: Heck Reaction, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reagent type: catalyst
reaction type: Cross Couplings, reaction type: Hiyama Coupling, reaction type: Suzuki-Miyaura Coupling

reaction suitability

core: palladium, reaction type: Sonogashira Coupling, reaction type: Suzuki-Miyaura Coupling, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reagent type: catalyst
reaction type: Cross Couplings, reaction type: Negishi Coupling, reaction type: Stille Coupling, reaction type: Buchwald-Hartwig Cross Coupling Reaction

reaction suitability

reaction type: Hiyama Coupling, reaction type: Heck Reaction, reaction type: Sonogashira Coupling, reagent type: catalyst
reaction type: Cross Couplings, reaction type: Stille Coupling, core: palladium, reaction type: Negishi Coupling, reaction type: Suzuki-Miyaura Coupling, reaction type: Buchwald-Hartwig Cross Coupling Reaction

assay

98%

assay

98%

assay

-

assay

95%

form

solid

form

solid

form

solid

form

solid

functional group

phosphine

functional group

phosphine

functional group

phosphine

functional group

phosphine

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

mp

202-210 °C

mp

146-151 °C (decomposition)

mp

218 °C (dec.)

mp

152-163 °C (decomposition)


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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