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774405

(S)-2-Aminobutane-1,4-dithiol hydrochloride

99% (titration)

Synonym(s):

(S)-2-Aminobutane-1,4-dithiol hydrochloride, (2S)-2-Amino-1,4-dimercaptobutane hydrochloride, DTBA, Dithiobutylamine

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About This Item

Empirical Formula (Hill Notation):
C4H11NS2 · HCl
CAS Number:
1363376-98-0
Molecular Weight:
173.73
NACRES:
NA.22
PubChem Substance ID:
329767683
UNSPSC Code:
12352200
MDL number:
MFCD23704430
Assay:
99% (titration)
Form:
solid
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Quality Level

100

assay

99% (titration)

form

solid

reaction suitability

reagent type: reductant

mp

210-225 °C

storage temp.

2-8°C

SMILES string

Cl.N[C@H](CS)CCS

InChI

1S/C4H11NS2.ClH/c5-4(3-7)1-2-6;/h4,6-7H,1-3,5H2;1H/t4-;/m0./s1

InChI key

HWWPXJZINVJNBM-WCCKRBBISA-N

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This Item
296651P7505SML0460
(S)-2-Aminobutane-1,4-dithiol hydrochloride 99% (titration)

Sigma-Aldrich

774405

(S)-2-Aminobutane-1,4-dithiol hydrochloride

(S)-(+)-sec-Butylamine 99%

Sigma-Aldrich

296651

(S)-(+)-sec-Butylamine

Putrescine dihydrochloride ≥98% (TLC)

Sigma-Aldrich

P7505

Putrescine dihydrochloride

Methylhexanamine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0460

Methylhexanamine hydrochloride

reaction suitability

reagent type: reductant

reaction suitability

-

reaction suitability

-

reaction suitability

-

assay

99% (titration)

assay

99%

assay

≥98% (TLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

400

Quality Level

100

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

room temp

mp

210-225 °C

mp

-

mp

280 °C (dec.) (lit.)

mp

-

form

solid

form

-

form

powder

form

powder

Application

Dithiobutylamine or DTBA is a new biological reducing reagent with enhanced properties over other commonly used reagents. DTBA was shown to reduce small molecule disulfides 3-5x faster than DTT and was able to reduce (activate) the cysteine dependent protease papain 14x faster than DTT. In addition, due to the presence of the primary amine group, removal of DTBA from mixtures after use is simplified and can be achieved using cation exchange resin.
(S)-2-Aminobutane-1,4-dithiol hydrochloride (DTBA), also known as dithiobutylamine, is a biological reducing reagent with enhanced properties over other commonly used reagents. DTBA was shown to reduce small molecule disulfides 3-5x faster than DTT and was able to reduce (activate) the cysteine dependent protease papain 14x faster than DTT. In addition, due to the presence of the primary amine group, removal of DTBA from mixtures after use is simplified and can be achieved using cation exchange resin.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB0850
MKCS9782
MKCR2407
MKCS6145
MKCQ4518

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Mozhdeh Imaninezhad et al.
Bioconjugate chemistry, 30(1), 34-46 (2018-12-19)
Macroporous cell-laden hydrogels have recently gained recognition for a wide range of biomedical and bioengineering applications. There are various approaches to create porosity in hydrogels, including lyophilization or foam formation. However, many do not allow a precise control over pore
A potent, versatile disulfide-reducing agent from aspartic acid.
Lukesh III, et al.
Journal of the American Chemical Society, 134(9), 4057-4059 (2012)
Coordination properties of dithiobutylamine (DTBA), a newly introduced protein disulfide reducing agent.
Adamczyk J, et al.
Inorganic Chemistry, 54(2), 596-606 (2014)
Javier Troyano et al.
Inorganic chemistry, 58(5), 3290-3301 (2019-02-13)
Direct reactions under ambient conditions between CuX (X = Br, I) and thiobenzamide (TBA) were carried out at different ratios, giving rise to the formation of a series of one-dimensional (1D) coordination polymers, (CPs) [CuI(TBA)] n (1), [Cu3I3(TBA)2] n (4)
Sean B Johnston et al.
PloS one, 10(1), e0116898-e0116898 (2015-01-22)
Phosphatase and tensin homologue deleted from chromosome ten (PTEN) is a lipid phosphatase tumor suppressor that is lost or inactivated in most human tumors. The enzyme catalyzes the hydrolysis of phosphatidylinositol-(3,4,5)-trisphosphate (PIP3) to form phosphatidylinositol-(4,5)-bisphosphate (PIP2) and inorganic phosphate. Here
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Global Trade Item Number

SKUGTIN
774405-1G04061832931333

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