PHR1566

D5 Cyclomethicone

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Decamethylcyclopentasiloxane
• Empirical Formula (Hill Notation): C₁₀H₃₀O₅Si₅
• CAS Number: 541-02-6
• Molecular Weight: 370.77
• Beilstein/REAXYS Number: 1800166
• EC Number: 208-764-9
• MDL number: MFCD00046966
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823475
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to USP 1154809
• API family: cyclomethicone
• CofA: current certificate can be downloaded
• packaging: pkg of 500 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.396 (lit.)
• bp: 90 °C/10 mmHg (lit.)
• density: 0.958 g/mL at 25 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1
• InChI: 1S/C10H30O5Si5/c1-16(2)11-17(3,4)13-19(7,8)15-20(9,10)14-18(5,6)12-16/h1-10H3
• InChI key: XMSXQFUHVRWGNA-UHFFFAOYSA-N

Description

General description

D5 Cyclomethicone is a cyclic siloxane, that has a silicon-oxygen bond in a cyclic arrangement and methyl groups attached with the silicon atom. It is used in the production of some silicon-based polymers that are widely used in various personal care products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

D5 Cyclomethicone may be used as a pharmaceutical reference standard for the determination of the analyte in personal care formulations by gas chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2966 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: 163.4 °F - closed cup
• flash_point_c: 73 °C - closed cup