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Key Documents

MABN607

Sigma-Aldrich

Anti-Neurexin-1-Beta Antibody

clone 170A/1, from mouse

Synonym(s):

Neurexin-1-beta, Neurexin I-beta

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

170A/1, monoclonal

species reactivity

rat, human

technique(s)

immunohistochemistry: suitable

isotype

IgG1κ

NCBI accession no.

NP_620072

UniProt accession no.

P58400

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... NRXN1(9378)

General description

Neurexin-1-beta or Neurexin I-beta is a neuronal cell surface protein thought to be involved in cell recognition and cell adhesion through the formation of intracellular junctions via binding to neuroligins. Neurexin-1-beta may also have roles in the formation and maintenance of synaptic junctions, mediation of intracellular signaling, and angiogenesis.

Specificity

This antibody recognizes the N-terminus within the extracellular domain of Neurexin-1-beta. This antibody does not cross-react with Neurexin1-alpha or Neurexin-2 (Prof. J. Trimmer, University of California, Davis.).

Immunogen

Epitope: N-terminus within the extracellular domain
Linear peptide corresponding to the N-terminus of human Neurexin-1-beta.

Application

Anti-Neurexin-1-Beta Antibody is a highly specific mouse monoclonal antibody, that targets Neurexin 1 & has been tested in IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Neurexin-1-beta in human cerebellum, rat frontal lobe, and human thalamus tissues.

Western Blotting Analysis: A representative lot detected Neurexin-1-beta in COS cell lysates transiently transfected with Flag-tagged Neurexin-1-beta, and demonstrated a loss of signal in COS cell lysates transiently transfected with Flag-tagged Neurexin-1-alpha or untagged Kv2.1 plasmids (Prof. J. Trimmer, University of California, Davis.).
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Quality

Evaluated by Immunohistochemistry in rat olfactory bulb tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Neurexin-1-beta in rat olfactory bulb tissue.

Target description

47 kDa calculated. This protein has been observed at ~70 kDa (Prof. J. Trimmer, University of California, Davis.). Uncharacterized band(s) may be observed in some cell lysates.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rat olfactory bulb tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ichiro Kawahata et al.
International journal of molecular sciences, 20(21) (2019-10-31)
α-Synuclein is an abundant neuronal protein that accumulates in insoluble inclusions in Parkinson's disease and other synucleinopathies. Fatty acids partially regulate α-Synuclein accumulation, and mesencephalic dopaminergic neurons highly express fatty acid-binding protein 3 (FABP3). We previously demonstrated that FABP3 knockout
Silas E Busch et al.
Frontiers in cellular neuroscience, 17, 1219270-1219270 (2023-08-07)
Cyfip1, the gene encoding cytoplasmic FMR1 interacting protein 1, has been of interest as an autism candidate gene for years. A potential role in autism spectrum disorder (ASD) is suggested by its location on human chromosome 15q11-13, an instable region
Yan Xu et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 47(7), 1292-1303 (2021-10-29)
Consolidated memories influence later learning and cognitive processes when new information is overlapped with previous events. To reveal which cellular and molecular factors are associated with this proactive interference, we challenged mice with odor-reward associative learning followed by a reversal-learning

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