MABS451
Anti-Linear Ubiquitin Antibody, clone LUB9
clone LUB9, from mouse
Synonym(s):
Polyubiquitin-C, Ubiquitin
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100 μG
$513.00
$513.00
Estimated to ship onApril 26, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB2114
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100 μG
$513.00
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
$513.00
Estimated to ship onApril 26, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB2114
Request a Bulk Order
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biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
LUB9, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... UBC(7316)
General description
Ubiquitin functions as a marker to indicate the fate of other proteins in the cell. It can be attached as a single molecule or as a polyubiquitin chain. Although ubiquitinated proteins are oftentimes tagged for degradation by the 20S proteosome, ubiquitination can also indicate alternative fates depending on the lysine residue that is involved in linking the ubiquitin chain to the target protein. Ubiquitin chains linked by Lys33 to kinase substrates such as AMP-activated protein kinases, (AMPKα1, BRSK1, MARK3, MARK4, and NUAK1), may activate or deactivate these proteins, supporting the role for uniquitin in regulating signaling.
Specificity
This antibody detects only Linear Ubiquitin.
Immunogen
Ovalbumin-conjugated linear peptide corresponding to human Linear Ubiquitin.
Application
Anti-Linear Ubiquitin Antibody, clone LUB9 | MABS451 is an antibody against Linear Ubiquitin Antibody for use in Western Blotting.
Research Category
Signaling
Signaling
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
Western Blotting Analysis: A representative lot detected Linear Ubiquitin in (M1-linked) ubiquitin chains (Yoshiteru, S. et al. (2013). EMBO. 32:2463-2476).
Quality
Evaluated by Western Blotting in recombinant protein Linear Polyubiquitin chains, K48 Ub 2-7, K63 Ub 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected 10 µg of Linear Polyubiquitin recombinant protein chains, bands were not detected in K48 Ub 2-7, K63 Ub 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected 10 µg of Linear Polyubiquitin recombinant protein chains, bands were not detected in K48 Ub 2-7, K63 Ub 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein.
Target description
Multiple bands observed
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Xiangqin Kuang et al.
Cellular & molecular biology letters, 28(1), 62-62 (2023-08-01)
Bladder cancer (BLCA) is a malignancy that frequently metastasizes and leads to poor patient prognosis. It is essential to understand the molecular mechanisms underlying the progression and metastasis of BLCA and identify potential biomarkers. The expression of peptidase inhibitor 16
Daisuke Oikawa et al.
Frontiers in immunology, 11, 601926-601926 (2020-12-18)
The LUBAC ubiquitin ligase complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits, stimulates the canonical nuclear factor-κB (NF-κB) activation pathways through its Met1-linked linear ubiquitination activity. Here we performed cellular and mathematical modeling analyses of the LUBAC involvement in
Daisuke Oikawa et al.
Communications biology, 3(1), 163-163 (2020-04-05)
The NF-κB and interferon antiviral signaling pathways play pivotal roles in inflammatory and innate immune responses. The LUBAC ubiquitin ligase complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits, activates the canonical NF-κB pathway through Met1-linked linear ubiquitination. We identified
Seshiru Nakazawa et al.
Nature communications, 7, 12547-12547 (2016-08-25)
Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the UBAN domain of OPTN reportedly abolishes its NF-κB suppressive activity, the precise molecular basis in ALS pathogenesis still remains unclear.
Esther Hoste et al.
Nature communications, 12(1), 5913-5913 (2021-10-10)
OTULIN is a deubiquitinase that specifically cleaves linear ubiquitin chains. Here we demonstrate that the ablation of Otulin selectively in keratinocytes causes inflammatory skin lesions that develop into verrucous carcinomas. Genetic deletion of Tnfr1, knockin expression of kinase-inactive Ripk1 or
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