Pituitary homeobox 3 (UniProt O75364; also known as Homeobox protein PITX3, Paired-like homeodomain transcription factor 3) is encoded by the PITX3 (also known as ASMD, CTPP4, CTRCT11, PTX3) gene (Gene ID 5309) in human. PITX3 is a bicoid-related homeodomain transcription factor critical for the development of the ocular lens, mesencephalic dopaminergic neurons and skeletal muscle. PITX3 exerts its developmental impact on dopaminergic neurons by directly regulating the expression of a cascade of downstream genes, including TH, VMAT2, DAT, BDNF, and GDNF. PITX3 and the related PITX2 are both key regulators of intracellular redox state and play an important role in preventing DNA damage during fetal myogenesis. Human PITX3 gene mutations are linked to cataracts and anterior segment abnormalities and PITX3 polymorphisms are associated with Parkinson′s disease. In aphakia (ak) mice, deletions in the Pitx3 promoter region cause abnormal lens development.
Immunogen
KLH-conjugated linear peptide corresponding to a sequence within the N-terminal region of human PITX3.
Application
Anti-PITX3 Antibody, clone 12G4.1 is an antibody against PITX3 for use in Western Blotting.
Quality
Evaluated by Western Blotting in human retinoblastoma Y79 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected PITX3 in 10 µg of human retinoblastoma Y79 cell lysate.
Target description
~32 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physical form
Format: Purified
Other Notes
Concentration: Please refer to lot specific datasheet.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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