Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.
Immunogen
KLH-conjugated linear peptide corresponding to human DISC1 near the N-terminus.
Application
Detect Disc1 using this rabbit polyclonal antibody, Anti-DISC1 Antibody validated for use in western blotting.
Quality
Evaluated by Western Blotting in human hippocampus tissue lysate.
Western Blotting Analysis: 0.1 µg/mL of this antibody detected DISC1 in 10 µg of human hippocampus tissue lysate.
Target description
~100 kDa observed. Uncharacterized band(s) may appear in some lysates.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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