Peptide YY (UniProt P10082; also known as Peptide tyrosine tyrosine, PYY, PYY-I) is encoded by the PYY (also known as PYY1) gene (Gene ID 5697) in human. Peptide YY is initially produced as a preproprotein with a signal and a propeptide sequence (aa 1-28 and aa 68-97, respectively). There are two major forms of mature peptide YY corresponding to aa 29-64 and aa 31-64 of the prepro sequence, commonly known as YY(1-36) and YY(3-36), respectively. PYY is one of several well recognized circulating anorexigenic peptides, whose productions increase post-prandially. PYY and glucagon-like peptide 1 (GLP-1) are released from L cells that predominate in the distal ileum and colon. The melanocortin-4 receptor (MC4R) is reported to mediate PYY and GLP-1 release from enteroendocrine L cells upon melanocortin peptides stimulation.
Specificity
Reacts with prepro-, pro-, and mature peptide YY & peptide YY(3-36).
Immunogen
Epitope: Mature Peptide YY
KLH-conjugated linear peptide corresponding to the mature human peptide YY.
Application
Anti-Peptide YY Antibody, Cat. No. ABN457, is a highly specific chicken Polyclonal antibody, that targets Peptide YY and has been tested in Western Blotting, Immunohistochemistry.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Peptide YY in rat colon tissue.
Quality
Evaluated by Western Blotting in rat small intestine tissue lysate.
Western Blotting Analysis: 0.25 µg/mL of this antibody detected Peptide YY in 10 µg of rat small intestine tissue lysate.
Target description
~11 kDa observed
Other Notes
Concentration: Please refer to lot specific datasheet.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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