524403

Pravastatin, Sodium Salt

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (K_i = ~1 nM).

• Synonym(s): Pravastatin, Sodium Salt, (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na
• CAS Number: 81131-70-6
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
• InChI key: VWBQYTRBTXKKOG-IYNICTALSA-M

Description

General description

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks in vivo cholesterol synthesis (K_i ~1 nM). Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (K_i = ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.

Biochem/physiol Actions

Cell permeable: no

Primary Target
AMG-CoA reductase

Product does not compete with ATP.

Reversible: no

Target K_i: ~1 nM inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocking in vivo cholesterol synthesis

Packaging

Packaged under inert gas

Warning

Toxicity: Environmental Hazard (N)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kwak, B., et al. 2000. Natl. Med.6, 1399.
Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci.19, 26.
Narisawa, T., et al. 1996. Jpn. J. Cancer Res.87, 798.
Cohen, L.H., et al. 1993. Biochem. Pharmacol.45, 2203.
Koga, T., et al. 1990. Biochim. Biophys. Acta.1045, 115.
Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable