155764

o-Phenylene phosphorochloridite

97%

• Synonym(s): 2-Chloro-1,3,2-benzodioxaphosphole, o-Phenylene chlorophosphite, Chloro(1,2-phenylenedioxy)phosphine, Cyclic o-phenylene phosphorochloridite, Phosphorochloridous acid orthophenylene ester, Pyrocatechol phosphoryl chloride
• Empirical Formula (Hill Notation): C₆H₄ClO₂P
• CAS Number: 1641-40-3
• Molecular Weight: 174.52
• Beilstein/REAXYS Number: 135455
• EC Number: 216-690-3
• MDL number: MFCD00005853
• UNSPSC Code: 12352005
• PubChem Substance ID: 24849564
• NACRES: NA.22

Properties

• assay: 97%
• form: solid
• reaction suitability: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling
• refractive index: n20/D 1.571 (lit.)
• bp: 80 °C/20 mmHg (lit.)
• mp: 30-35 °C (lit.)
• density: 1.466 g/mL at 25 °C (lit.)
• SMILES string: ClP1Oc2ccccc2O1
• InChI: 1S/C6H4ClO2P/c7-10-8-5-3-1-2-4-6(5)9-10/h1-4H
• InChI key: YUJYEGDMJZHLMY-UHFFFAOYSA-N

Description

Application

• Catalyst in synthesis of bakkane sesquiterpenes
• Reactant in reversible halogen-halogen ligand substitution at room temperature, and in irreversible halogen-O substitution at higher temperatures
• Reactant in preparation of gold(I) trimethoxybenzonitrile phosphine isolated precatalysts
• Reactant for preparation of pyrroles by TMSOTf-catalyzed Arbuzov reaction
• Phosphorylation agent
• Reactant for reparation of vinyl-substituted spirophosphoranes and vinylphosphonates via Markovnikov addition

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 230.0 °F - closed cup
• flash_point_c: 110 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges