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15490

Sigma-Aldrich

Boc-Pro-OH

≥99.0% (T)

Synonym(s):

N-(tert-Butoxycarbonyl)-L-proline, Boc-L-proline

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About This Item

Empirical Formula (Hill Notation):
C10H17NO4
CAS Number:
15761-39-4
Molecular Weight:
215.25
Beilstein/REAXYS Number:
15828
EC Number:
239-848-3
MDL number:
MFCD00037324
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
57647368
NACRES:
NA.22

assay

≥99.0% (T)

form

solid

optical activity

[α]20/D −61±2°, c = 2% in acetic acid

reaction suitability

reaction type: Boc solid-phase peptide synthesis

mp

133-135 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(C)(C)OC(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m0/s1

InChI key

ZQEBQGAAWMOMAI-ZETCQYMHSA-N

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Manos Gkikas et al.
Biomacromolecules, 16(11), 3686-3693 (2015-10-16)
Novel poly(L-lysine)-block-poly(L-proline) (PLL-b-PLP)-based materials with all PLP helical conformers, i.e., PLP II and the rare PLP I are here reported. Electrostatic supramolecular complexation of the adjacent cationic PLL with anionic molecules bearing DNA analogue H-bonding functionalities, such as deoxyguanosine monophosphate
Griet Van Zeebroeck et al.
Nature chemical biology, 5(1), 45-52 (2008-12-09)
Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting transceptors is unknown. We have screened 319 amino acid analogs to identify compounds that act on Gap1

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Proline Derivatives and Analogs

Proline analogues are promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occuring, as well as de novo designed, linear, and, cyclic peptides.

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