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145521

Sigma-Aldrich

4-(Methylthio)benzoic acid

97%

Synonym(s):

4-(Methylmercapto)benzoic acid

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About This Item

Linear Formula:
CH3SC6H4CO2H
CAS Number:
13205-48-6
Molecular Weight:
168.21
Beilstein/REAXYS Number:
2082809
EC Number:
236-171-5
MDL number:
MFCD00002555
UNSPSC Code:
12352100
PubChem Substance ID:
24848733
NACRES:
NA.22

assay

97%

mp

192-196 °C (lit.)

SMILES string

CSc1ccc(cc1)C(O)=O

InChI

1S/C8H8O2S/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3,(H,9,10)

InChI key

KWHCPERWLHBLOT-UHFFFAOYSA-N

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General description

Administration of 4-(methylthio)benzoic acid reduces cisplatin nephrotoxicity in rats. It prevents in vitro DNA binding and mutation induction in Escherichia coli K12.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P J Boogaard et al.
Biochemical pharmacology, 41(12), 1997-2003 (1991-06-15)
Administration of 4-methylthiobenzoic acid (MTBA) (100 mg/kg) strongly reduced cisplatin nephrotoxicity (7.5 mg/kg, 20 min after MTBA) in rats as determined by histopathology and blood urea nitrogen. Anti-tumour activity against a colonic adenocarcinoma, CC 531, that was implanted in rats
E D Kroese et al.
Mutation research, 245(2), 67-74 (1990-10-01)
Thioethers are effective scavengers of electrophilic metabolites derived from the hepatocarcinogen N-hydroxy-2-acetylaminofluorene (van den Goorbergh et al., 1987). In this study 2 of these thioethers, 4-(methylthio)benzoic acid (MTB) and its methylester, methyl 4-(methylthio)benzoate (MMTB), have been tested for their ability

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