SML0119

Acrivastine

≥98% (HPLC)

• Synonym(s): (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid
• Empirical Formula (Hill Notation): C₂₂H₂₄N₂O₂
• CAS Number: 87848-99-5
• Molecular Weight: 348.44
• NACRES: NA.77
• PubChem Substance ID: 329825170
• UNSPSC Code: 12352200
• MDL number: MFCD00869830
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: >2 mg/mL (warmed)
• storage temp.: 2-8°C
• SMILES string: Cc1ccc(cc1)\C(=C/CN2CCCC2)c3cccc(\C=C\C(O)=O)n3
• InChI: 1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
• InChI key: PWACSDKDOHSSQD-IUTFFREVSA-N
• Gene Information: human ... HRH1(3269)

Description

Application

Acrivastine has been used as an antihistamine to investigate the relation between the increased residence time of antihistamine at the histamine H1 receptor (H1R) and the duration of effective target-inhibition by this antagonist.

Biochem/physiol Actions

Acrivastine is a second-generation H1-receptor antagonist.

Acrivastine is a second-generation antihistamine, an H1-receptor antagonist.

Acrivastine is a second-generation antihistamine. It is a derivative of first-generation compound triprolidine. Acrivastine is effectively used for treating allergic diseases including cholinergic urticaria and histamine-medicated dermatoses.[1]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable