S5451

Sarpogrelate hydrochloride

≥98% (HPLC)

• Synonym(s): Anplag, Butanedioic acid 1-[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester hydrochloride, MCI 9042, Succinic acid mono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)et hyl]phenoxy)ethyl) ester hydrochloride
• Empirical Formula (Hill Notation): C₂₄H₃₁NO_6.HCl
• CAS Number: 135159-51-2
• Molecular Weight: 465.97
• MDL number: MFCD00887582
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824454
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: deionized water: ≥5 mg/mL
• storage temp.: room temp
• SMILES string: Cl.COc1cccc(CCc2ccccc2OCC(CN(C)C)OC(=O)CCC(O)=O)c1
• InChI: 1S/C24H31NO6.ClH/c1-25(2)16-21(31-24(28)14-13-23(26)27)17-30-22-10-5-4-8-19(22)12-11-18-7-6-9-20(15-18)29-3;/h4-10,15,21H,11-14,16-17H2,1-3H3,(H,26,27);1H
• InChI key: POQBIDFFYCYHOB-UHFFFAOYSA-N

Description

General description

Sarpogrelate hydrochloride binds to the serotonin receptor (5-hydroxytryptamine, 5-HT2A). Its binding to 5-HT2A receptor inhibits thrombus formation and reduces platelet aggregation. Sarpogrelate hydrochloride has been used as an anti-atherosclerotic agent. It improves the endothelial function and may be useful for treating peripheral arterial disease. Use of sarpogrelate hydrochloride as 5-HT2A antagonist reduces urinary albumin levels in diabetic nephropathy.

Biochem/physiol Actions

Sarapogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist. It exhibits analgesic effects in numerous animal studies.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H410
• pcodes: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable