P6777

Phenelzine sulfate salt

Name: Phenelzine sulfate salt
Brand: SIGMA
Price: 448 USD
Availability: InStock

synthetic, ≥98% (iodine, titration), MAO-A/B inhibitor, powder

Synonym(s):

Phenelzine hydrogen sulphate

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5 G

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₂N₂ · H₂O₄S

CAS Number:

156-51-4

Molecular Weight:

234.27

NACRES:

NA.77

PubChem Substance ID:

24278646

UNSPSC Code:

12352200

EC Number:

205-856-0

MDL number:

MFCD00050687

Assay:

≥98% (iodine, titration)

Form:

powder

Quality level:

200

Key Documents

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Product Name

Phenelzine sulfate salt,

biological source

synthetic

Quality Level

200

assay

≥98% (iodine, titration)

form

powder

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

NNCCC1=CC=CC=C1.OS(=O)(O)=O

InChI

1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)

InChI key

RXBKMJIPNDOHFR-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128), MAOB(4129)

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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Show Differences

1 of 4

This Item	1517006	BP1166	P1761
Sigma-Aldrich P6777 Phenelzine sulfate salt	USP 1517006 Phenelzine sulfate	BP1166 Phenelzine sulfate	Sigma-Aldrich P1761 trans-2-Phenylcyclopropylamine hemisulfate salt
assay ≥98% (iodine, titration)	assay -	assay -	assay ≥98% (perchloric acid titration)
form powder	form -	form solid	form powder
Quality Level 200	Quality Level -	Quality Level -	Quality Level 200
solubility water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow	solubility -	solubility -	solubility water: 0.0333 g/mL, clear to slightly hazy, colorless to faintly yellow
biological source synthetic	biological source -	biological source -	biological source -
Gene Information human ... MAOA(4128), MAOB(4129)	Gene Information human ... MAOA(4128), MAOB(4129)	Gene Information human ... MAOA(4128), MAOB(4129)	Gene Information -

Biochem/physiol Actions

Non-selective MAO-A/B inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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The effect of riluzole augmentation in a patient with treatment-resistant obsessive-compulsive disorder, taking two other glutaminergic agents.

Nahla Mahgoub et al.

The Journal of neuropsychiatry and clinical neurosciences, 23(2), E24-E25 (2011-06-17)

Phenelzine (monoamine oxidase inhibitor) increases production of nitric oxide and proinflammatory cytokines via the NF-κB pathway in lipopolysaccharide-activated microglia cells.

Hwan-Suck Chung et al.

Neurochemical research, 37(10), 2117-2124 (2012-07-06)

Phenelzine is a potent monoamine oxidase inhibitor that is used in patients with depression. It is also well known that nitric oxide (NO) synthase inhibitors show preclinical antidepressant-like properties, which suggests that NO is involved in the pathogenesis of depression.

The antidepressant phenelzine protects neurons and astrocytes against formaldehyde-induced toxicity.

Mee-Sook Song et al.

Journal of neurochemistry, 114(5), 1405-1413 (2010-06-19)

Reactive aldehydes have been implicated in the etiology of several neurological and psychiatric disorders, and there is considerable interest in drugs to counteract the actions of these aldehydes. Increased formaldehyde (FA) and up-regulation of semicarbazide-sensitive amine oxidase, which forms FA

Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system.

Marco De Giovanni et al.

Immunity, 56(7), 1548-1560 (2023-06-07)

Cryptococcus neoformans is the leading cause of fungal meningitis and is characterized by pathogenic eosinophil accumulation in the context of type-2 inflammation. The chemoattractant receptor GPR35 is expressed by granulocytes and promotes their migration to the inflammatory mediator 5-hydroxyindoleacetic acid

The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE).

Travis Musgrave et al.

Brain, behavior, and immunity, 25(8), 1677-1688 (2011-07-05)

Multiple sclerosis (MS) and the animal model, experimental autoimmune encephalomyelitis (EAE), are both accompanied by motor and non-motor symptoms. Pathological changes in the activities of key neurotransmitters likely underlie many of these symptoms. We have previously described disturbances in the

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Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Global Trade Item Number

SKU	GTIN
P6777-25G	04061832948478
P6777-5G	04061834394013

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