M5518

Mezerein

from Daphne mezereum, ≥97% (HPLC)

• Synonym(s): 12β-[(E,E)-5-Phenyl-2,4-pentadienoyloxy]daphnetoxin
• Empirical Formula (Hill Notation): C₃₈H₃₈O₁₀
• CAS Number: 34807-41-5
• Molecular Weight: 654.70
• PubChem Substance ID: 24897019
• UNSPSC Code: 12352200
• Beilstein/REAXYS Number: 1675867
• MDL number: MFCD00135953

Properties

• biological source: Daphne mezereum
• assay: ≥97% (HPLC)
• storage temp.: −20°C
• SMILES string: [H][C@@]12C=C(C)C(=O)[C@@]1(O)[C@H](O)[C@@]3(CO)O[C@H]3C4[C@H]5OC6(O[C@]5([C@H](OC(=O)\C=C\C=C\c7ccccc7)[C@@H](C)[C@]24O6)C(C)=C)c8ccccc8
• InChI: 1S/C38H38O10/c1-21(2)36-30(44-27(40)18-12-11-15-24-13-7-5-8-14-24)23(4)37-26-19-22(3)29(41)35(26,43)33(42)34(20-39)31(45-34)28(37)32(36)46-38(47-36,48-37)25-16-9-6-10-17-25/h5-19,23,26,28,30-33,39,42-43H,1,20H2,2-4H3/b15-11+,18-12+/t23-,26-,28?,30-,31+,32-,33-,34+,35-,36+,37+,38?/m1/s1
• InChI key: DLEDLHFNQDHEOJ-WNRHQEOASA-N

Description

Biochem/physiol Actions

Potent second stage tumor promotor and inflammatory agent; activates protein kinase C at nanomolar concentrations.

Other Notes

Phorbol ester analog from the plant Daphne mezereum.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H317
• pcodes: P280 - P302 + P352
• Hazard Classifications: Skin Irrit. 2 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves