M5319

Matrine

• Synonym(s): Matridin-15-one, Sophocarpidine
• Empirical Formula (Hill Notation): C₁₅H₂₄N₂O
• CAS Number: 519-02-8
• Molecular Weight: 248.36
• MDL number: MFCD00210527
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818010
• NACRES: NA.25

Properties

• Quality Level: 100
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• SMILES string: O=C1CCCC2C3CCCN4CCCC(CN12)C34
• InChI: 1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
• InChI key: ZSBXGIUJOOQZMP-JLNYLFASSA-N

Description

General description

Matrine (MT) or Sophocarpidine is a naturally occurring bioactive compound, extracted from traditional Chinese herbs like Sophora flavescens and Radix Sophorae tonkinensis.[1]

Application

Matrine has been used:

• to study its antioxidant and protective effect on doxorubicin (DOX)-induced cardiotoxicity in mice model and H9C2 cells[2]
• as a chemotherapeutic agent to test its inhibitory effect on the growth of human glioblastoma multiforme (GBM) cells[3], and ovarian cancer cells[4]
• to study its effect on mitochondrial fission and its anti-tumor functionality in HepG2 cells[5]
• as a necroptosis inducer in cholangiocarcinoma (CCA) cell lines[6]

Biochem/physiol Actions

Matrine is a potent therapeutic agent with various pharmacological like anti-cancer, anti-bacterial, anti-fibrotic, anti-inflammatory properties.[1] It is a macropinocytosis inducer and decreases the cellular adenosine triphosphate (ATP) level.[7] Matrine may also serve as an effective sedative agent.[8] It serves as an anti-inflammatory agent in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced intestinal inflammation in mice.[9] It functions to reverse the Warburg effect and suppress the growth of human colon cancer cells.[10]

Matrine is an alkaloid that is one of the major components in the root of the saphoro plant. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves