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M3189

Sigma-Aldrich

Mepivacaine hydrochloride

98.0-102.0%, meets USP testing specifications

Synonym(s):

1-Methyl-2′,6′-pipecoloxylidine hydrochloride, N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O · HCl
CAS Number:
1722-62-9
Molecular Weight:
282.81
EC Number:
217-023-9
MDL number:
MFCD00144738
UNSPSC Code:
12352200
PubChem Substance ID:
57654370

agency

meets USP testing specifications

assay

98.0-102.0%

originator

Novocol

SMILES string

CN1CCCCC1C(NC2=C(C)C=CC=C2C)=O.Cl

InChI

1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H

InChI key

RETIMRUQNCDCQB-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Biochem/physiol Actions

Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novocol. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H336

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

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Mylène Lecours et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 60(3), 244-252 (2012-12-06)
In recent studies on ultrasound-guided infraclavicular block (ICB), the authors have favoured a single injection posterior to the axillary artery rather than multiple injections; however, procedural complications and success rates associated with single-injection ultrasound-guided ICB are not well known. We
Kaoru Hara et al.
Regional anesthesia and pain medicine, 37(3), 289-293 (2012-04-06)
The present study was conducted to determine the incidence of unintentional intraneural injection during ultrasound-guided subgluteal sciatic nerve block using a low-frequency transducer. We also observed the effects of intraneural injection using ropivacaine and mepivacaine. Enrolled in the study were
T Kjelstrup et al.
Acta anaesthesiologica Scandinavica, 56(7), 914-919 (2012-05-11)
Axillary block is the most commonly performed brachial plexus block and may be guided by nerve stimulation or ultrasound. Magnetic resonance imaging (MRI) has proven to be beneficial in presenting anatomy of interest for regional anaesthesia and in demonstrating spread
Christopher J Snyder et al.
Journal of the American Veterinary Medical Association, 242(2), 199-204 (2013-01-02)
To evaluate the effects of a routinely used infraorbital nerve block, performed for dental procedures, on the anesthetic requirement for isoflurane in dogs. Prospective controlled study. 8 healthy adult Beagles. Dogs were anesthetized with isoflurane, and the minimum alveolar concentration
Jeff Gadsden et al.
Anesthesia and analgesia, 115(4), 963-967 (2012-07-17)
During peripheral nerve blockade, different local anesthetics may be sequentially administered. Typically, a short- or intermediate-acting local anesthetic is administered before a long-acting local anesthetic to achieve a block with rapid onset and long duration. However, there is a paucity
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Chromatograms

application for HPLC

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