M1508

4-Methylumbelliferone sodium salt

fluorogenic, ≥98% (HPLC), crystalline

• Synonym(s): β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin
• Linear Formula: C₁₀H₇O₃Na
• CAS Number: 5980-33-6
• Molecular Weight: 198.15
• EC Number: 227-790-1
• MDL number: MFCD00069856
• UNSPSC Code: 12352204
• PubChem Substance ID: 24896658
• NACRES: NA.32

Properties

• Product Name: 4-Methylumbelliferone sodium salt, ≥98% (HPLC), crystalline
• Quality Level: 200
• assay: ≥98% (HPLC)
• form: crystalline
• color: yellow
• solubility: water: 50 mg/mL
• SMILES string: [Na+].CC1=CC(=O)Oc2cc([O-])ccc12
• InChI: 1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
• InChI key: JGMQHDNPUCPRQE-UHFFFAOYSA-M

Description

General description

4-methylumbelliferone (4-MU) is a coumarin derivative.[1]

Application

4-Methylumbelliferone sodium salt has been used:

• as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver[2]
• as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action[3]
• in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer[4]

Biochem/physiol Actions

4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic[5], and antitumor properties.[1] 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response.[5] 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.[2]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)