I7003

Ibogaine hydrochloride

• Empirical Formula (Hill Notation): C₂₀H₂₆N₂O · HCl
• CAS Number: 5934-55-4
• Molecular Weight: 346.89
• UNSPSC Code: 12352200
• EC Number: 227-687-1
• MDL number: MFCD00167426

Properties

• drug control: USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
• solubility: H₂O: soluble, methanol: soluble
• application(s): forensics and toxicology
• SMILES string: Cl.CCC1CC2CC3C1N(CCc4c3[nH]c5ccc(OC)cc45)C2

Description

Biochem/physiol Actions

CNS stimulant and hallucinogen; anti-convulsant.

Ibogaine is a central nervous system stimulant and hallucinogen that has been reported to be a σ₂ agonist, a noncompetitive NMDA receptor antagonist at the phencyclidine site and an enhancer of purinergic muscle contractions. It is also a competitive inhibitor of serotonin and dopamine transport. It is an anti-convulsant and has anti-addictive properties against cocaine and heroin.

Preparation Note

Alkaloid isolated from the African shrub, Tabernanthe iboga.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves