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B5887

Sodium butyrate

≥98.5% (GC)

Synonym(s):

Butyric acid sodium salt

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Pack SizeSKUAvailabilityPrice
250 mg
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$49.80
1 g
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$171.00
5 g
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$531.00

About This Item

Linear Formula:
CH3CH2CH2COONa
CAS Number:
Molecular Weight:
110.09
UNSPSC Code:
12352107
NACRES:
NA.25
PubChem Substance ID:
EC Number:
205-857-6
Beilstein/REAXYS Number:
3629439
MDL number:

$49.80


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biological source

synthetic (organic)

Quality Level

assay

≥98.5% (GC)

form

powder

storage condition

(Tightly closed. Dry.
Keep in a dry place. )

technique(s)

DNA amplification: suitable, cell based assay: suitable, inhibition assay: suitable

color

white

mp

250-253 °C (lit.)

solubility

water: 100 mg/mL, clear to slightly hazy, colorless

cation traces

Na: 19.8-22.0% (anhydrous)

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This Item
3034101613600567430
biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

assay

≥98.5% (GC)

assay

98%

assay

-

assay

≥98% (titration)

Gene Information

mouse ... ENSMUSG00000061062(15181)

Gene Information

mouse ... ENSMUSG00000061062(15181)

Gene Information

-

Gene Information

-

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

200

form

powder

form

powder

form

-

form

solid

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

−20°C

Application

Sodium butyrate has been used:
  • as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
  • as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
  • to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Biochem/physiol Actions

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Disclaimer

Hygroscopic

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells
Cody JJ, et al.
PLoS ONE, 9(3), e92919-e92919 (2014)
Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero
Tea JS, et al.
The Journal of Neuroscience, 30(29), 9939-9946 (2010)
Na-butyrate sustains energetic states of metabolism and t-PA productivity of CHO cells
McMurray-Beaulieu V, et al.
Journal of Bioscience and Bioengineering, 108(2), 160-167 (2009)
Jiangping He et al.
Nature communications, 10(1), 34-34 (2019-01-04)
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst TEs are increasingly recognized for their important biological functions, they are a potential danger to genomic stability and are carefully regulated by the epigenetic system. However, the full
Ras Trokovic et al.
Stem cell research, 15(1), 254-262 (2015-06-23)
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSC) by the forced expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC. Pluripotent reprogramming appears as a slow and inefficient process because of genetic and epigenetic barriers of

Articles

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

Global Trade Item Number

SKUGTIN
B5887-5G04061833434222
B5887-1G04061835505944
B5887-250MG04061835542895

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. I would like to know which is the recommended solvent to make dilutions with Sodium butyrate B5887, they are meant for long-term storage.

    1 answer
    1. This product is soluble in water at 100 mg/mL. The filter-sterilized solution is stable for up to 2 years at 2-8°C as indicated for the 500mM prepared solution, product TR-1008.

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