07748
Gabapentin
pharmaceutical secondary standard; traceable to USP
Synonym(s):
1-(Aminomethyl)-cyclohexaneacetic acid, Neurontin
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About This Item
Empirical Formula (Hill Notation):
C9H17NO2
CAS Number:
Molecular Weight:
171.24
EC Number:
262-076-3
UNSPSC Code:
41116000
MDL number:
Beilstein/REAXYS Number:
2359739
InChI key
UGJMXCAKCUNAIE-UHFFFAOYSA-N
InChI
1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
SMILES string
NCC1(CC(O)=O)CCCCC1
agency
traceable to USP 1287303
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Y Yu et al.
Clinical pharmacology and therapeutics, 94(4), 519-524 (2013-05-28)
To investigate the so-called "drift" with generic-generic drug substitution, a single-dose, four-way crossover comparative bioavailability study was performed involving 24 healthy subjects and three generic and one branded formulation of a tablet containing 800 mg gabapentin as test medication. The results
Barbara J Mason et al.
JAMA internal medicine, 174(1), 70-77 (2013-11-06)
Approved medications for alcohol dependence are prescribed for less than 9% of US alcoholics. To determine if gabapentin, a widely prescribed generic calcium channel/γ-aminobutyric acid-modulating medication, increases rates of sustained abstinence and no heavy drinking and decreases alcohol-related insomnia, dysphoria
Carlos C Câmara et al.
Neuroscience letters, 556, 93-98 (2013-10-22)
Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain. This study aimed at evaluating whether oral GBP treatment could improve nerve inflammation response after sciatic nerve constriction in association with selected pain and motor spontaneous
O A Petroff et al.
Annals of neurology, 39(1), 95-99 (1996-01-01)
Gabapentin has come into clinical use as adjunctive therapy in the treatment of epilepsy. Designed to mimic gamma-aminobutyric acid (GABA), its mechanism of action remains elusive. In vivo measurements of GABA in human brain were made using 1H magnetic resonance
Érica C Marchiori et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(12), 2115-2122 (2013-09-03)
To estimate the prevalence of, risk factors for, and clinical course of neuropathic pain (NPP) after sagittal split ramus osteotomy (SSRO) of the mandible in a large cohort of patients. A retrospective cohort of all patients who underwent SSRO at
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