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861324

Sigma-Aldrich

p-Rosolic acid

Dye content 84 %

Synonym(s):

4-[Bis(4-hydroxyphenyl)methylene]-2,5-cyclohexadienone, Aurin

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About This Item

Empirical Formula (Hill Notation):
C19H14O3
CAS Number:
603-45-2
Molecular Weight:
290.31
Colour Index Number:
43800
Beilstein/REAXYS Number:
2055205
EC Number:
210-041-8
MDL number:
MFCD00001624
UNSPSC Code:
12171500
PubChem Substance ID:
24888536
NACRES:
NA.47

form

powder

Quality Level

200

composition

Dye content, 84%

technique(s)

titration: suitable

pH

5.0-6.8, yellow to pink

cation traces

C: 66.0-90.8%

λmax

482 nm

ε (extinction coefficient)

≥11000 at 264-270 nm in ethanol
≥50000 at 478-486 nm in ethanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

O=C(C=C1)C=CC1=C(C2=CC=C(O)C=C2)C3=CC=C(O)C=C3

InChI

1S/C19H14O3/c20-16-7-1-13(2-8-16)19(14-3-9-17(21)10-4-14)15-5-11-18(22)12-6-15/h1-12,20-21H

InChI key

FYEHYMARPSSOBO-UHFFFAOYSA-N

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General description

p-Rosolic acid (C.I. 43800) is an acid-baseindicator from the triphenylmethane group. It is also known as aurin and 4-[Bis(4-hydroxyphenyl)methylene]-2,5-cyclohexadienone.

Application

p-Rosolic acid has been used to induce cellular stress in HEK293 cells.

Biochem/physiol Actions

The transition range of p-Rosolic acid is around pH 6.6-8.0 (Below this pH range it is yellow and above it red).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous detection of the subcellular localization of RNAs and proteins in cultured cells by combined multicolor RNA-FISH and IF.
Meyer C, et al.
Methods, S1046-2023 (2016)
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Rivista critica di clinica medica, 45(6-9), 484-493 (1945-11-30)
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International journal of radiation biology, 75(12), 1567-1578 (2000-01-06)
To investigate the mechanism of micronucleus formation in irradiated L929 cells. Radiation-induced micronuclei (MN) of L929 cells isolated at 48 and 72 h after irradiation were processed for detection of DNA-laddering and higher-order chromatin fragments using conventional gel electrophoresis and
A Batistatou et al.
The Journal of cell biology, 122(3), 523-532 (1993-08-01)
Serum-free PC12 cell cultures have been used to study the mechanisms of neuronal death after neurotrophic factor deprivation. We previously reported that PC12 cells undergo "apoptotic" internucleosomal DNA cleavage after withdrawal of trophic support. Here, we have used a sensitive
J Chen et al.
Thrombosis research, 66(2-3), 111-120 (1992-05-01)
To determine whether heparin potentiation of platelet aggregation is related to platelet GP IIb/IIIa and GP Ib receptors, four series of experiments were performed on blood from normal volunteers. In the first experiment pretreatment with the monoclonal antibody 7E3 (MAb
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