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712191

COMU®

greener alternative

≥96.5% (TLC), for peptide synthesis

Synonym(s):

(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate

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Size/SKUAvailabilityPrice
5 g

Available to ship TODAYfromMILWAUKEE

$86.90
25 g

Available to ship TODAYfromMILWAUKEE

$306.00
100 g

Available to ship TODAYfromMILWAUKEE

$811.00

About This Item

Empirical Formula (Hill Notation):
C12H19F6N4O4P
CAS Number:
Molecular Weight:
428.27
UNSPSC Code:
12352107
PubChem Substance ID:
NACRES:
NA.22
MDL number:

$86.90


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Product Name

COMU®, 97%

Quality Segment

assay

≥96.5% (TLC), 96.5-103.5% (T), 97%

form

crystals

reaction suitability

reaction type: Coupling Reactions

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

application(s)

peptide synthesis

functional group

amine, ester, ether, nitrile

greener alternative category

storage temp.

2-8°C

SMILES string

F[P-](F)(F)(F)(F)F.CCOC(=O)C(=NO\C(N1CCOCC1)=[N+](/C)C)C#N

InChI

1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;

InChI key

GPDHNZNLPKYHCN-DZOOLQPHSA-N

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention". Click here for more information.

Application

COMU – Safer and More Efficient Peptide Coupling Reagent

Advantages
  • Equal or even superior performance to HATU
  • Non-explosive (does not contain benzotriazole moiety)
  • Suitable for solution phase & solid phase peptide synthesis
  • Utmost retention of configuration – low to non-existent racemization
  • High solubility and stability in typical solvents
  • Visual or colorimetric reaction monitoring possible
  • Easy removal of water-soluble by-products

Legal Information

COMU is a registered trademark of Luxembourg Bio Technologies Ltd.

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1 of 1

This Item
6631318.5108563675
form

crystals

form

solid

form

powder

form

-

functional group

amine, ether, ester, nitrile

functional group

phosphine

functional group

-

functional group

-

assay

≥96.5% (TLC), 97%, 96.5-103.5% (T)

assay

98%

assay

≥99.0% (HPLC)

assay

≥98.5% (sum of enantiomers, GC)

storage temp.

2-8°C

storage temp.

-

storage temp.

-10 to -25°C

storage temp.

−20°C

Quality Level

100

Quality Level

300

Quality Level

300

Quality Level

100

greener alternative category

, Aligned

greener alternative category

Re-engineered,

greener alternative category

Aligned

greener alternative category

Re-engineered,


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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