TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms:
ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11
Species:
Human TAP2 (6891), Mouse Tap2 (21355), Rat Tap2 (24812), chicken TAP2 (427728), Thale Cress TAP2 (833896), naked mole-rat Tap2 (101703007), domestic guinea pig Tap2 (100717574), sheep TAP2 (101109491), Horse TAP2 (100052423), cow TAP2 (281586) ...More
UniProtKB ID:
Gene ID:
- Human(6891) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Jul 2008]
- Mouse(21355) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- Rat(24812) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- chicken(427728) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- Thale Cress(833896) ABC transporter B family member 27
- naked mole-rat(101703007) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- domestic guinea pig(100717574) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- sheep(101109491) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- Horse(100052423) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- cow(281586) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- dog(474864) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- domestic cat(101089770) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TAP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-TAP2 Antibody, clone 429.4, clone 429.4, from mouse,
Species Reactivity
human
Application
immunocytochemistry
western blot
western blot