STIL
SCL/TAL1 interrupting locus
Synonyms:
MCPH7, SIL
Species:
Human STIL (6491), Mouse Stil (20460), Rat Stil (313506), Zebrafish stil (192317), fruit fly stil (36380), domestic guinea pig Stil (100712956), dog STIL (610305), naked mole-rat Stil (101704338), sheep STIL (101106636), chicken STIL (424621) ...More
UniProtKB ID:
Gene ID:
- Human(6491) Summary: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(20460) Scl/Tal1 interrupting locus
- Rat(313506) Scl/Tal1 interrupting locus
- Zebrafish(192317) TAL1 (SCL) interrupting locus
- fruit fly(36380) stand still
- domestic guinea pig(100712956) SCL/TAL1 interrupting locus
- dog(610305) SCL/TAL1 interrupting locus
- naked mole-rat(101704338) SCL/TAL1 interrupting locus
- sheep(101106636) SCL/TAL1 interrupting locus
- chicken(424621) SCL/TAL1 interrupting locus
- cow(510012) SCL/TAL1 interrupting locus
- Horse(100051410) SCL/TAL1 interrupting locus
- domestic cat(101097659) SCL/TAL1 interrupting locus
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Stil Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-STIL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
esiRNA
Product Number
Description
Species