SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Synonyms:
ACP33, GL010, MAST
Species:
Human SPG21 (51324), Mouse Spg21 (27965), Rat Spg21 (300791), domestic cat SPG21 (101096987), dog SPG21 (487599), Zebrafish spg21 (406704), domestic guinea pig Spg21 (100713790), cow SPG21 (404069), sheep SPG21 (101117420), naked mole-rat Spg21 (101696663)
UniProtKB ID:
Gene ID:
- Human(51324) Summary: The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(27965) spastic paraplegia 21 homolog (human)
- Rat(300791) spastic paraplegia 21 homolog (human)
- domestic cat(101096987) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- dog(487599) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- Zebrafish(406704) spastic paraplegia 21 (H. sapiens)
- domestic guinea pig(100713790) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- cow(404069) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- sheep(101117420) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- naked mole-rat(101696663) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
- chicken(415526) spastic paraplegia 21 (autosomal recessive, Mast syndrome)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SPG21 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-SPG21 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-SPG21 antibody produced in mouse, clone 2B11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA