PRKG1
protein kinase, cGMP-dependent, type I
Synonyms:
1, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha
Species:
Human PRKG1 (5592), Mouse Prkg1 (19091), Rat Prkg1 (54286), chicken PRKG1 (423682), Horse PRKG1 (100071872), naked mole-rat Prkg1 (101708361), sheep PRKG1 (100294616), sheep PRKG1 (101117124), domestic cat PRKG1 (101097420), domestic guinea pig Prkg1 (100734084) ...More
UniProtKB ID:
Gene ID:
- Human(5592) Summary: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
- Mouse(19091) protein kinase, cGMP-dependent, type I
- Rat(54286) protein kinase, cGMP-dependent, type 1
- chicken(423682) protein kinase, cGMP-dependent, type I
- Horse(100071872) protein kinase, cGMP-dependent, type I
- naked mole-rat(101708361) protein kinase, cGMP-dependent, type I
- sheep(100294616) protein kinase, cGMP-dependent, type I
- sheep(101117124) protein kinase, cGMP-dependent, type I
- domestic cat(101097420) protein kinase, cGMP-dependent, type I
- domestic guinea pig(100734084) protein kinase, cGMP-dependent, type I
- dog(609616) protein kinase, cGMP-dependent, type I
- Domestic Rabbit(100008694) protein kinase, cGMP-dependent, type I
- cow(282004) protein kinase, cGMP-dependent, type I
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ELISA
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PRKG1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-PRKG1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-PRKG1 antibody produced in mouse, clone 2B3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-PRKG1 antibody produced in mouse, clone 5E5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
ANTI-CGKI (CGKI BETA)(C-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
PRKG1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
Protein Kinase G Iβ human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution,
Species
human
PKG1α Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1α. For use in Kinase Assays.,
Species
human
PKG1alpha active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Species
human
PKG1β Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1β, for use in Kinase Assays.,
Species
human