PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
Synonyms:
PDH, PDP, PDPC, PPM2C
Species:
Human PDP1 (54704), Mouse Pdp1 (381511), Rat Pdp1 (54705), domestic cat PDP1 (101082975), domestic guinea pig Pdp1 (100718641), naked mole-rat Pdp1 (101724432), dog PDP1 (477941), chicken PDP1 (428372), Zebrafish pdp1 (558728), sheep PDP1 (101111813) ...More
UniProtKB ID:
Gene ID:
- Human(54704) Summary: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
- Mouse(381511) pyruvate dehyrogenase phosphatase catalytic subunit 1
- Rat(54705) pyruvate dehyrogenase phosphatase catalytic subunit 1
- domestic cat(101082975) pyruvate dehyrogenase phosphatase catalytic subunit 1
- domestic guinea pig(100718641) pyruvate dehyrogenase phosphatase catalytic subunit 1
- naked mole-rat(101724432) pyruvate dehyrogenase phosphatase catalytic subunit 1
- dog(477941) pyruvate dehyrogenase phosphatase catalytic subunit 1
- chicken(428372) pyruvate dehyrogenase phosphatase catalytic subunit 1
- Zebrafish(558728) pyruvate dehyrogenase phosphatase catalytic subunit 1
- sheep(101111813) pyruvate dehyrogenase phosphatase catalytic subunit 1
- cow(280891) pyruvate dehyrogenase phosphatase catalytic subunit 1
- fruit fly(45588) PAR-domain protein 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PDP1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-Protein Phosphatase 2 C α/β Antibody, from rabbit,
Species Reactivity
bovine, human, mouse, rat
Application
western blot