P4HB
prolyl 4-hydroxylase, beta polypeptide
Synonyms:
DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
Species:
Human P4HB (5034), Mouse P4hb (18453), Rat P4hb (25506), sheep P4HB (100135700), Zebrafish p4hb (406673), sheep P4HB (101115218), chicken P4HB (374091), naked mole-rat P4hb (101712215), cow P4HB (281373), dog P4HB (483369) ...More
UniProtKB ID:
Gene ID:
- Human(5034) Summary: This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
- Mouse(18453) prolyl 4-hydroxylase, beta polypeptide
- Rat(25506) prolyl 4-hydroxylase, beta polypeptide
- sheep(100135700) prolyl 4-hydroxylase, beta polypeptide
- Zebrafish(406673) procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
- sheep(101115218) prolyl 4-hydroxylase, beta polypeptide
- chicken(374091) prolyl 4-hydroxylase, beta polypeptide
- naked mole-rat(101712215) prolyl 4-hydroxylase, beta polypeptide
- cow(281373) prolyl 4-hydroxylase, beta polypeptide
- dog(483369) prolyl 4-hydroxylase, beta polypeptide
- domestic guinea pig(100733944) prolyl 4-hydroxylase, beta polypeptide
- Domestic Rabbit(100328595) prolyl 4-hydroxylase, beta polypeptide
- domestic cat(101099917) prolyl 4-hydroxylase, beta polypeptide
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-P4HB (AB2) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, mouse, pig, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-PDI Antibody, clone 1M19 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-P4HB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-P4HB antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-P4HB antibody produced in rabbit, ,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species