MMP14
matrix metallopeptidase 14 (membrane-inserted)
Synonyms:
MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1
Species:
Human MMP14 (4323), Mouse Mmp14 (17387), Rat Mmp14 (81707), naked mole-rat Mmp14 (101723795), sheep MMP14 (443116), cow MMP14 (281915), Domestic Rabbit MMP14 (100009598), domestic guinea pig Mmp14 (100732039), dog MMP14 (403823), Horse MMP14 (100034170) ...More
UniProtKB ID:
Gene ID:
- Human(4323) Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
- Mouse(17387) matrix metallopeptidase 14 (membrane-inserted)
- Rat(81707) matrix metallopeptidase 14 (membrane-inserted)
- naked mole-rat(101723795) matrix metallopeptidase 14 (membrane-inserted)
- sheep(443116) matrix metallopeptidase 14 (membrane-inserted)
- cow(281915) matrix metallopeptidase 14 (membrane-inserted)
- Domestic Rabbit(100009598) matrix metallopeptidase 14 (membrane-inserted)
- domestic guinea pig(100732039) matrix metallopeptidase 14 (membrane-inserted)
- dog(403823) matrix metallopeptidase 14 (membrane-inserted)
- Horse(100034170) matrix metallopeptidase 14 (membrane-inserted)
- domestic cat(101089776) matrix metallopeptidase 14 (membrane-inserted)
- chicken(426253) matrix metallopeptidase 14 (membrane-inserted)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MMP14 (Cleaved-Tyr112) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-MMP-14 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MMP14/MT1-MMP antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-MMP-14 Antibody, catalytic domain, clone LEM-2/15.8, clone LEM-2/15.8, Chemicon®, from mouse,
Species Reactivity
human, mouse
Application
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-MT1-MMP (Ab-4) Mouse mAb (113-5B7), liquid, clone 113-5B7, Calbiochem®,
Species Reactivity
human, mouse, rabbit, rat
Application
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
MMP-14, human, prodomain, catalytic domain, and hemopexin domain, E. coli recombinant, ,
Species
human