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GGTLC2

gamma-glutamyltransferase light chain 2

Synonyms:
GGTL4
Species:
Human GGTLC2 (91227)
UniProtKB ID:
Q14390, A1A516, A2VCM9, Q5NV76, Q6ISH0
Gene ID:
  • Human(91227) Summary: Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC2, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]

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