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CASP5

caspase 5, apoptosis-related cysteine peptidase

Synonyms:
ICE(rel)III, ICEREL-III, ICH-3
Species:
Human CASP5 (838)
UniProtKB ID:
P51878, B4DKP5, Q0QVY7, Q0QVY8, Q0QVZ0, Q0QVZ1, Q0QVZ2, Q14DD6
Gene ID:
  • Human(838) Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4503304
Anti-CASP5 (p10, Cleaved-Ser331) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
ABS445
Anti-Caspase-5 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
immunocytochemistry
immunofluorescence
western blot
PRS3455
Anti-Caspase-5 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
HPA040937
Anti-CASP5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Proteins

Product Number
Description
Species
C6482
Caspase 5 human, recombinant, expressed in E. coli, 5,000 units/mg protein,
Species
human

esiRNA

Product Number
Description
Species
EHU127011
MISSION® esiRNA, targeting human CASP5,
Species
human