CASP4
caspase 4, apoptosis-related cysteine peptidase
Synonyms:
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Species:
Human CASP4 (837), Mouse Casp4 (12363), Rat Casp4 (114555), dog CASP4 (403724), naked mole-rat Casp4 (101700797), domestic guinea pig Casp4 (100731032), cow CASP4 (338039)
UniProtKB ID:
Gene ID:
- Human(837) Summary: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
- Mouse(12363) caspase 4, apoptosis-related cysteine peptidase
- Rat(114555) caspase 4, apoptosis-related cysteine peptidase
- dog(403724) caspase 4, apoptosis-related cysteine peptidase
- naked mole-rat(101700797) caspase 4, apoptosis-related cysteine peptidase
- domestic guinea pig(100731032) caspase 4, apoptosis-related cysteine peptidase
- cow(338039) caspase 4, apoptosis-related cysteine peptidase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Caspase-4 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-CASP4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Caspase-13 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Caspase 11 antibody produced in rat, clone 17D9, purified from hybridoma cell culture,
Species Reactivity
mouse
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Caspase-4, clone 17D9 Antibody, clone 17D9, from rat,
Species Reactivity
human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Proteins
Product Number
Description
Species
esiRNA
Small Molecule - Substrate
Product Number
Description
Species
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin, ≥95% (HPLC), powder,
Species
rat, mouse, human