BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
Synonyms:
BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP
Species:
Human BTRC (8945), Mouse Btrc (12234), Rat Btrc (361765), domestic guinea pig Btrc (100730107), sheep BTRC (101101939), cow BTRC (534072), naked mole-rat Btrc (101726740), domestic cat BTRC (101097596), Horse BTRC (100070200), dog BTRC (486851) ...More
UniProtKB ID:
Gene ID:
- Human(8945) Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
- Mouse(12234) beta-transducin repeat containing protein
- Rat(361765) beta-transducin repeat containing E3 ubiquitin protein ligase
- domestic guinea pig(100730107) beta-transducin repeat containing E3 ubiquitin protein ligase
- sheep(101101939) beta-transducin repeat containing E3 ubiquitin protein ligase
- cow(534072) beta-transducin repeat containing
- naked mole-rat(101726740) beta-transducin repeat containing E3 ubiquitin protein ligase
- domestic cat(101097596) beta-transducin repeat containing E3 ubiquitin protein ligase
- Horse(100070200) beta-transducin repeat containing E3 ubiquitin protein ligase
- dog(486851) beta-transducin repeat containing E3 ubiquitin protein ligase
- chicken(423854) beta-transducin repeat containing
- Domestic Rabbit(100350519) beta-transducin repeat containing E3 ubiquitin protein ligase
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Antibodies
Product Number
Description
Species Reactivity
Application
ANTI-BRTC1/2(N-TERMINAL) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot
ANTI-BTRC (N-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-BTRC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
esiRNA
Product Number
Description
Species